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Details on Person Ubiquitylation of TRAF6 by TRAF3IP2 after IL17:IL17R interaction

Class:Id	Reaction:8980295
_displayName	Ubiquitylation of TRAF6 by TRAF3IP2 after IL17:IL17R interaction
_doRelease	FALSE
_timestamp	2017-08-14 13:47:37
catalystActivity	[CatalystActivity:8980281] ubiquitin protein ligase activity of IL17RA:IL17RC:IL17A dimer,IL17F dimer,IL17A:IL17F:TRAF3IP2:TRAF6 [cytosol]
catalystActivityReference	[CatalystActivityReference:9643982] ubiquitin protein ligase activity of IL17RA:IL17RC:IL17A dimer,IL17F dimer,IL17A:IL17F:TRAF3IP2:TRAF6 [cytosol] Act1, a U-box E3 ubiquitin ligase for IL-17 signaling
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:8980292] Duenas, Corina, 2017-02-27
input	[Complex:8979764] IL17RA:IL17RC:IL17A dimer,IL17F dimer,IL17A:IL17F:TRAF3IP2:TRAF6 [cytosol] [Homo sapiens] [Polymer:450152] K63polyUb [cytosol] [Homo sapiens] [Complex:202463] UBE2N:UBE2V1 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:8980280] Act1, a U-box E3 ubiquitin ligase for IL-17 signaling
modified	[InstanceEdit:8983529] Jupe, Steve, 2017-03-24 [InstanceEdit:9015115] Duenas, Corina, 2017-08-08 [InstanceEdit:9016491] Duenas, Corina, 2017-08-14 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9643047] Wu, G, 2019-04-04
name	Ubiquitylation of TRAF6 by TRAF3IP2 after IL17:IL17R interaction
output	[Complex:8980241] IL17A dimer,IL17F dimer,IL17A:IL17F:IL17RA:IL17RC:TRAF3IP2:K63polyUb-TRAF6:UBE2N:UBE2V1 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:8980293] TRAF6 binds IL17RA:IL17RC:IL17A dimer,IL17F dimer,IL17A:IL17F:TRAF3IP2 complex [Homo sapiens] [Reaction:8951104] TRAF3IP2 binds IL17RA:IL17RC:IL17A dimer,IL17F dimer,IL17A:IL17F:TRAF3IP2 complex [Homo sapiens]
regulatedBy	[NegativeRegulation:8980299] Negative regulation by 'ANAPC5:TNFAIP3:2xIL17A,2xIL17F,IL17A:IL17F:IL17RA:IL17RC:TRAF3IP2:K63polyUb-TRAF6 [plasma membrane]' [NegativeRegulation:8980309] Negative regulation by 'TNFAIP3:2xIL17A,2xIL17F,IL17A:IL17F:IL17RA:IL17RC:TRAF3IP2:K63polyUb-TRAF6 [plasma membrane]' [NegativeRegulation:8980337] Negative regulation by 'USP25 [cytosol]'
regulationReference	[RegulationReference:9641739] Negative regulation by 'ANAPC5:TNFAIP3:2xIL17A,2xIL17F,IL17A:IL17F:IL17RA:IL17RC:TRAF3IP2:K63polyUb-TRAF6 [plasma membrane]' The anaphase-promoting complex protein 5 (AnapC5) associates with A20 and inhibits IL-17-mediated signal transduction [RegulationReference:9641969] Negative regulation by 'USP25 [cytosol]' Negative regulation of IL-17-mediated signaling and inflammation by the ubiquitin-specific protease USP25 [RegulationReference:9642351] Negative regulation by 'TNFAIP3:2xIL17A,2xIL17F,IL17A:IL17F:IL17RA:IL17RC:TRAF3IP2:K63polyUb-TRAF6 [plasma membrane]' The deubiquitinase A20 mediates feedback inhibition of interleukin-17 receptor signaling
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8980302] R-HSA-8980295.1
summation	[Summation:8980290] Adapter protein CIKS (TRAF3IP2, ACT1), a receptor-proximal c...
(hasEvent)	[Pathway:448424] Interleukin-17 signaling [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:8980352] TAK1:TAB2:TAB3 complex binds K63-polyUb-TRAF6 [Homo sapiens] [BlackBoxEvent:8980383] TNFAIP3 binds IL17RA [Homo sapiens]
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