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Details on Person TRAF6 binds IL17RA:IL17RC:IL17A dimer,IL17F dimer,IL17A:IL17F:TRAF3IP2 complex
Class:Id Reaction:8980293 _displayName TRAF6 binds IL17RA:IL17RC:IL17A dimer,IL17F dimer,IL17A:IL17F:TRAF3IP2 complex _doRelease FALSE _timestamp 2017-08-14 13:47:26 compartment [Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane created [InstanceEdit:8980292] Duenas, Corina, 2017-02-27 input [Complex:8979704] IL17RA:IL17RC:IL17A dimer,IL17F dimer,IL17A:IL17F:TRAF3IP2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:166366] TRAF6 [cytosol] [Homo sapiens] isChimeric FALSE literatureReference [LiteratureReference:8980297] Requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transduction modified [InstanceEdit:8983528] Jupe, Steve, 2017-03-24 [InstanceEdit:8983815] Duenas, Corina, 2017-03-29 [InstanceEdit:8983831] Duenas, Corina, 2017-03-29 [InstanceEdit:9015115] Duenas, Corina, 2017-08-08 [InstanceEdit:9016491] Duenas, Corina, 2017-08-14 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 name TRAF6 binds IL17RA:IL17RC:IL17A dimer,IL17F dimer,IL17A:IL17F:TRAF3IP2 complex output [Complex:8979764] IL17RA:IL17RC:IL17A dimer,IL17F dimer,IL17A:IL17F:TRAF3IP2:TRAF6 [cytosol] [Homo sapiens] precedingEvent
regulatedBy [PositiveRegulation:8980306] Positive regulation by 'HSP90AA1,HSP90AB1 [cytosol]' [NegativeRegulation:8980316] Negative regulation by 'TRAF4 [cytosol]' [PositiveRegulation:8983595] Positive regulation by 'HSPA (HSP70) proteins [nucleoplasm]' regulationReference [RegulationReference:9641201] Negative regulation by 'TRAF4 [cytosol]' Cutting edge: TNF receptor-associated factor 4 restricts IL-17-mediated pathology and signaling processes [RegulationReference:9641622] Positive regulation by 'HSPA (HSP70) proteins [nucleoplasm]' The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90 [RegulationReference:9642649] Positive regulation by 'HSP90AA1,HSP90AB1 [cytosol]' The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90 species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:8980301] R-HSA-8980293.1 summation [Summation:8980291] As a result of Adapter protein CIKS (TRAF3IP2, ACT1) recruit... (hasEvent) [Pathway:448424] Interleukin-17 signaling [Homo sapiens] (precedingEvent) [Reaction:8980295] Ubiquitylation of TRAF6 by TRAF3IP2 after IL17:IL17R interaction [Homo sapiens] [Reaction:8980328] IKBKE phosphorylates TRAF3IP2 in IL17RA:IL17RC:IL17A dimer,IL17F dimer,IL17A:IL17F:TRAF3IP2:TRAF6 complex [Homo sapiens] [BlackBoxEvent:8980491] TBK1 phosphorylates TRAF3IP2 in IL17RA:IL17RC:IL17A dimer,IL17F dimer,IL17A:IL17F:TRAF3IP2:TRAF6:TBK1 complex [Homo sapiens] [BlackBoxEvent:8983593] TBK1 binds a TRAF3IP2 complex [Homo sapiens] [BlackBoxEvent:8983597] IKBKE binds TRAF3IP2 in IL17RA:IL17RC:IL17A dimer, IL17F dimer,IL17A:IL17F:TRAF3IP2:TRAF6 complex [Homo sapiens]
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No pathways have been reviewed or authored by TRAF6 binds IL17RA:IL17RC:IL17A dimer,IL17F dimer,IL17A:IL17F:TRAF3IP2 complex (8980293)
