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Details on Person Adapter protein CIKS (TRAF3IP2, ACT1), a receptor-proximal c...
| Class:Id | Summation:8980290 |
|---|---|
| _displayName | Adapter protein CIKS (TRAF3IP2, ACT1), a receptor-proximal c... |
| _timestamp | 2017-10-04 09:12:16 |
| created | [InstanceEdit:8980292] Duenas, Corina, 2017-02-27 |
| literatureReference | [LiteratureReference:8979803] Negative regulation of IL-17-mediated signaling and inflammation by the ubiquitin-specific protease USP25 [LiteratureReference:8979733] Curcumin nanoformulations: a future nanomedicine for cancer [LiteratureReference:8980298] The anaphase-promoting complex protein 5 (AnapC5) associates with A20 and inhibits IL-17-mediated signal transduction [LiteratureReference:8980120] The deubiquitinase A20 mediates feedback inhibition of interleukin-17 receptor signaling |
| modified | [InstanceEdit:8983806] Duenas, Corina, 2017-03-29 [InstanceEdit:8983953] Duenas, Corina, 2017-03-31 [InstanceEdit:8983964] Jupe, Steve, 2017-03-31 [InstanceEdit:8983974] Jupe, Steve, 2017-03-31 [InstanceEdit:8986318] Duenas, Corina, 2017-04-25 [InstanceEdit:9024462] Duenas, Corina, 2017-10-04 |
| text | Adapter protein CIKS (TRAF3IP2, ACT1), a receptor-proximal component of the Interleukin-17(IL17) signaling pathway, is a U-box-type E3 ubiquitin ligase. The U-box-mediated E3 ligase activity of TRAF3IP2 is crucial for Interleukin-17-induced downstream signaling events, including the activation of Nuclear factor NF-kappa-B (NFKB), Mitogen-activated protein kinases and the expression of genes encoding proinflammatory factors. TRAF3IP2 mediated Lys63- linked ubiquitination of TNF receptor-associated factor 6 (TRAF6) is an important component of the Interleukin-17 receptor signaling pathway. TRAF3IP2-mediated ubiquitination of TRAF6 occurs on Lysine-124. This is required for Interleukin-17-induced activation of NFKB (Yallapu et al.2012). Ubiquitin carboxyl-terminal hydrolase 25 (USP25) acts as a negative regulator of IL17 signaling by deubiquitinating TRAF6 and TNF receptor-associated factor 5 (TRAF5) in the Interleukin-17 receptor complex. Interleukin-17 stimulation induced the association of Ubiquitin carboxyl-terminal hydrolase 25 (USP25) with TRAF5 and TRAF6 and the USP25-induced removal of TRAF3IP2-mediated K63-linked ubiquitination of TRAF5 and TRAF6 (Zhang et al. 2012). Negative regulator, Tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20) negatively regulates IL17 signaling. It interacts directly with the distal domain of IL17R. IL17 stimulates overexpression of TNFAIP3 (Garg et al.2013). Anaphase-promoting complex subunit 5 (ANAPC5) can bind TNFAIP3, therefore, it participates in the negative feedback regulation of IL17 signal transduction (Ho et al.2013). |
| (summation) | [Reaction:8980295] Ubiquitylation of TRAF6 by TRAF3IP2 after IL17:IL17R interaction [Homo sapiens] |
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No pathways have been reviewed or authored by Adapter protein CIKS (TRAF3IP2, ACT1), a receptor-proximal c... (8980290)
