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Details on Person UniProt:Q96JJ3 ELMO2
| Class:Id | ReferenceGeneProduct:89800 |
|---|---|
| _chainChangeLog | chain:1-720 added on Fri February 6 2015 |
| _displayName | UniProt:Q96JJ3 ELMO2 |
| _timestamp | 2024-11-03 19:40:48 |
| chain | chain:1-720 |
| checksum | A67377E3B26F2937 |
| comment | FUNCTION Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.SUBUNIT Interacts with the SH3-domain of DOCK1 via its SH3-binding site. Probably part of a complex with DOCK1 and RAC1. Probably part of a complex with DOCK1 and CRK isoform CRK-II. Interacts with ARHGEF16, DOCK4 and EPHA2; mediates activation of RAC1 by EPHA2 (PubMed:20679435). Interacts with ADGRB3 (PubMed:24567399). Interacts with AUTS2; the interaction is direct (By similarity).INTERACTION Widely expressed, with a higher expression in skeletal muscle, kidney and placenta.DISEASE The disease is caused by variants affecting the gene represented in this entry.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Extended N-terminus. |
| description | recommendedName: Engulfment and cell motility protein 2 alternativeName: Protein ced-12 homolog A shortName: hCed-12A |
| geneName | ELMO2 CED12A KIAA1834 |
| identifier | Q96JJ3 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Apoptosis Cytoplasm Membrane Phagocytosis Phosphoprotein Proteomics identification Reference proteome SH3-binding |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | ELMO2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8998281] ENSEMBL:ENSG00000062598 ELMO2 [Homo sapiens] |
| secondaryIdentifier | ELMO2_HUMAN E1P5T3 Q5JVZ6 Q7Z5G9 Q96CJ2 Q96ME5 Q96PA9 Q9H938 Q9H9L5 Q9HAH0 Q9NQQ6 |
| sequenceLength | 720 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8974258] UniProt:Q96JJ3-1 ELMO2 [Homo sapiens] [ReferenceIsoform:8974259] UniProt:Q96JJ3-3 ELMO2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:372642] ELMO2 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q96JJ3 ELMO2 (89800)
