Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Diagram of Ketone body metabolism

Class:IdPathwayDiagram:8979166
_displayNameDiagram of Ketone body metabolism
_timestamp2017-02-21 22:23:46
created[InstanceEdit:8979167] D'Eustachio, Peter, 2017-02-21
height685
modified[InstanceEdit:8979168] D'Eustachio, Peter, 2017-02-21
representedPathway[Pathway:74182] Ketone body metabolism [Homo sapiens]
storedATXML<?xml version="1.0" encoding="UTF-8"?> <Process nextId="9220" reactomeDiagramId="8979166"> <Properties> <displayName>Diagram of Ketone body metabolism</displayName> </Properties> <Nodes> <org.gk.render.RenderableCompartment id="16" reactomeId="70101" position="689 354" bounds="26 31 1326 646" textPosition="640 627" bgColor="250 240 240" lineColor="255 153 102" insets="36 41 1304 624"> <Properties> <displayName>cytosol</displayName> </Properties> <Components> <Component id="2164" /> <Component id="2168" /> <Component id="2170" /> <Component id="2172" /> <Component id="2163" /> <Component id="2162" /> <Component id="2166" /> <Component id="4499" /> <Component id="4501" /> <Component id="4503" /> <Component id="4505" /> <Component id="4497" /> <Component id="4498" /> <Component id="5160" /> <Component id="5161" /> <Component id="5162" /> <Component id="5164" /> <Component id="117" /> <Component id="2165" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableCompartment id="117" reactomeId="5460" position="387 365" bounds="85 108 605 515" textPosition="533 174" bgColor="250 240 240" lineColor="255 153 102" insets="97 118 582 495"> <Properties> <displayName>mitochondrial matrix</displayName> </Properties> <Components> <Component id="224" /> <Component id="366" /> <Component id="260" /> <Component id="261" /> <Component id="262" /> <Component id="367" /> <Component id="263" /> <Component id="264" /> <Component id="368" /> <Component id="265" /> <Component id="266" /> <Component id="369" /> <Component id="267" /> <Component id="268" /> <Component id="269" /> <Component id="270" /> <Component id="271" /> <Component id="370" /> <Component id="371" /> <Component id="272" /> <Component id="273" /> <Component id="372" /> <Component id="275" /> <Component id="8557" /> <Component id="8558" /> <Component id="8559" /> <Component id="8560" /> <Component id="8562" /> <Component id="8765" /> <Component id="8767" /> <Component id="9163" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableChemical id="224" reactomeId="73871" position="319 159" bounds="281 144 77 30" textPosition="288 148" /> <org.gk.render.RenderableComplex id="260" reactomeId="70839" position="250 230" bounds="218 211 65 39" textPosition="221 215" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>ACAT1 tetramer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="261" reactomeId="113559" position="257 325" bounds="223 310 68 30" textPosition="231 314" /> <org.gk.render.RenderableChemical id="262" reactomeId="29374" position="184 155" bounds="150 140 68 30" textPosition="157 144"> <Properties> <displayName>CoA-SH</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="263" reactomeId="73917" position="431 315" bounds="397 300 68 30" textPosition="399 304"> <Properties> <displayName>HMG CoA</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableProtein id="264" reactomeId="56573" position="373 267" bounds="343 256 60 22" textPosition="344 256"> <Properties> <displayName>HMGCS2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="265" reactomeId="73909" position="433 408" bounds="412 393 42 30" textPosition="417 397"> <Properties> <displayName>ACA</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="266" reactomeId="74264" position="487 351" bounds="456 334 63 34" textPosition="460 333" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>HMGCL dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="267" reactomeId="73911" position="517 549" bounds="492 534 51 30" textPosition="497 538"> <Properties> <displayName>bHBA</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="268" reactomeId="74280" position="432 480" bounds="399 461 67 39" textPosition="403 465" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>BDH1 tetramer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="269" reactomeId="113529" position="335 418" bounds="318 403 34 30" textPosition="321 407" /> <org.gk.render.RenderableChemical id="270" reactomeId="29362" position="541 412" bounds="516 397 51 30" textPosition="520 401" /> <org.gk.render.RenderableChemical id="271" reactomeId="113526" position="360 550" bounds="335 535 51 30" textPosition="338 539"> <Properties> <displayName>NAD+</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="272" reactomeId="70958" position="615 390" bounds="573 375 85 30" textPosition="581 379"> <Properties> <displayName>SUCC-CoA</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="273" reactomeId="113536" position="607 266" bounds="577 251 60 30" textPosition="584 255"> <Properties> <displayName>SUCCA</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="275" reactomeId="29374" position="473 253" bounds="439 238 68 30" textPosition="446 242" /> <org.gk.render.RenderableChemical id="2163" reactomeId="113592" position="1048 230" bounds="1027 215 42 30" textPosition="1032 219" /> <org.gk.render.RenderableChemical id="2164" reactomeId="29666" position="1010 201" bounds="989 186 42 30" textPosition="994 190" /> <org.gk.render.RenderableChemical id="2165" reactomeId="191293" position="1257 201" bounds="1219 186 77 30" textPosition="1226 190"> <Properties> <displayName>ACA-CoA</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableProtein id="2166" reactomeId="5694468" position="1107 156" bounds="1086 145 43 22" textPosition="1088 145"> <Properties> <displayName>AACS</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="2168" reactomeId="76194" position="1027 159" bounds="993 144 68 30" textPosition="1000 148" /> <org.gk.render.RenderableChemical id="2170" reactomeId="111294" position="1194 168" bounds="1177 153 34 30" textPosition="1181 157" /> <org.gk.render.RenderableChemical id="2172" reactomeId="76577" position="1199 232" bounds="1178 217 42 30" textPosition="1182 221"> <Properties> <displayName>AMP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="4498" reactomeId="5696461" position="742 203" bounds="717 188 51 30" textPosition="722 192"> <Properties> <displayName>3HBA</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="4499" reactomeId="5696462" position="843 138" bounds="805 120 76 36" textPosition="814 121" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>BDH2 tetramer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="4501" reactomeId="29360" position="751 160" bounds="726 145 51 30" textPosition="729 149" /> <org.gk.render.RenderableChemical id="4503" reactomeId="73473" position="941 239" bounds="916 224 51 30" textPosition="920 228"> <Properties> <displayName>NADH</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="4505" reactomeId="70106" position="912 155" bounds="895 140 34 30" textPosition="898 144"> <Properties> <displayName>H+</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="5161" reactomeId="191374" position="853 293" bounds="811 278 85 30" textPosition="816 282"> <Properties> <displayName>bHMG-CoA</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="5162" reactomeId="6788595" position="942 344" bounds="890 333 105 22" textPosition="891 334" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>HMGCLL1:Mg2+</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="5164" reactomeId="76183" position="1089 293" bounds="1055 278 68 30" textPosition="1063 282"> <Properties> <displayName>Ac-CoA</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="8558" reactomeId="113593" position="302 479" bounds="284 464 36 30" textPosition="286 468"> <Properties> <displayName>ATP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="8559" reactomeId="113539" position="256 511" bounds="220 496 72 30" textPosition="223 500"> <Properties> <displayName>CH3COO-</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableProtein id="8560" reactomeId="5696385" position="193 419" bounds="170 408 47 22" textPosition="171 408"> <Properties> <displayName>ACSS3</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="8562" reactomeId="29374" position="202 480" bounds="173 464 58 32" textPosition="175 469" /> <org.gk.render.RenderableChemical id="8765" reactomeId="159448" position="204 368" bounds="183 353 42 30" textPosition="187 357" /> <org.gk.render.RenderableChemical id="8767" reactomeId="159450" position="303 379" bounds="286 364 34 30" textPosition="290 368"> <Properties> <displayName>PPi</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableEntitySet id="9163" reactomeId="8955621" position="613 319" bounds="570 308 86 22" textPosition="570 308"> <Properties> <displayName>OXCT dimers</displayName> </Properties> </org.gk.render.RenderableEntitySet> </Nodes> <Edges> <org.gk.render.RenderableReaction id="366" reactomeId="73916" points="269 307, 319 249, 319 229, 318 206" position="319 229" lineWidth="1.0"> <Inputs> <Input id="261" stoichiometry="2" /> </Inputs> <Outputs> <Output id="224" points="318 177" /> <Output id="262" points="221 167" /> </Outputs> <Catalysts> <Catalyst id="260" points="286 229" /> </Catalysts> <Properties> <displayName>2 acetyl-CoA &lt;=&gt; acetoacetyl-CoA + CoA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="367" reactomeId="73918" points="428 229, 429 268, 429 283" position="429 268" lineWidth="1.0"> <Inputs> <Input id="224" points="350 177, 428 211" /> <Input id="261" points="274 307, 370 228" /> </Inputs> <Outputs> <Output id="263" points="430 297" /> <Output id="275" points="451 271" /> </Outputs> <Catalysts> <Catalyst id="264" points="406 267" /> </Catalysts> <Properties> <displayName>acetoacetyl-CoA+acetyl-CoA =&gt; HMG-CoA + CoASH</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="368" reactomeId="74180" points="431 333, 431 352, 431 372" position="431 352" lineWidth="1.0"> <Inputs> <Input id="263" /> </Inputs> <Outputs> <Output id="265" points="432 390" /> <Output id="261" points="294 335, 415 373" /> </Outputs> <Catalysts> <Catalyst id="266" points="453 351" /> </Catalysts> <Properties> <displayName>HMG CoA =&gt; acetoacetic acid + acetyl CoA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="369" reactomeId="73912" points="357 458, 358 479, 359 497" position="358 479" lineWidth="1.0"> <Inputs> <Input id="265" points="409 421" /> <Input id="269" points="343 436" /> <Input id="270" points="513 418" /> </Inputs> <Outputs> <Output id="267" points="489 540" /> <Output id="271" points="359 532" /> </Outputs> <Catalysts> <Catalyst id="268" points="396 479" /> </Catalysts> <Properties> <displayName>acetoacetic acid + NADH + H+ &lt;=&gt; beta-hydroxybutyrate + NAD+</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="370" reactomeId="73920" points="516 498, 516 478, 515 460" position="516 478" lineWidth="1.0"> <Inputs> <Input id="267" points="516 531" /> <Input id="271" points="389 541" /> </Inputs> <Outputs> <Output id="265" points="457 421" /> <Output id="269" points="355 421" /> <Output id="270" points="532 430" /> </Outputs> <Catalysts> <Catalyst id="268" points="469 479" /> </Catalysts> <Properties> <displayName>D-beta hydroxybutyrate+NAD+ &lt;=&gt; acetoacetate+NADH+H+</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="371" reactomeId="74177" points="526 371, 527 321, 526 284" position="527 321" lineWidth="1.0"> <Inputs> <Input id="272" points="570 380" /> <Input id="265" points="457 399" /> </Inputs> <Outputs> <Output id="273" points="574 272" /> <Output id="224" points="361 166, 526 202" /> </Outputs> <Catalysts> <Catalyst id="9163" points="564 320" /> </Catalysts> <Properties> <displayName>OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="372" reactomeId="74181" points="184 191, 184 231, 185 257, 241 307" position="184 231" lineWidth="1.0"> <Inputs> <Input id="224" points="278 168" /> <Input id="262" points="184 173" /> </Inputs> <Outputs> <Output id="261" stoichiometry="2" /> </Outputs> <Catalysts> <Catalyst id="260" points="215 230" /> </Catalysts> <Properties> <displayName>acetoacetyl-CoA + CoA &lt;=&gt; 2 acetyl-CoA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2162" reactomeId="5694494" points="1079 200, 1111 200, 1147 200" position="1111 200" lineWidth="1.0"> <Inputs> <Input id="2163" points="1063 212" /> <Input id="2164" points="1034 200" /> <Input id="2168" points="1046 177" /> </Inputs> <Outputs> <Output id="2165" points="1216 200" /> <Output id="2170" points="1174 179" /> <Output id="2172" points="1175 219" /> </Outputs> <Catalysts> <Catalyst id="2166" points="1108 170" /> </Catalysts> <Properties> <displayName>AACS ligates CoA-SH to ACA, forming ACA-CoA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="4497" reactomeId="5696457" points="811 202, 842 202, 885 201" position="842 202" lineWidth="1.0"> <Inputs> <Input id="4498" points="771 202" /> <Input id="4501" points="772 178" /> </Inputs> <Outputs> <Output id="2164" points="986 201" /> <Output id="4503" points="918 221" /> <Output id="4505" points="903 173" /> </Outputs> <Catalysts> <Catalyst id="4499" points="842 159" /> </Catalysts> <Properties> <displayName>BDH2 dehydrogenates 3HBA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="5160" reactomeId="6788597" points="899 293, 940 293, 1009 293" position="940 293" lineWidth="1.0"> <Inputs> <Input id="5161" /> </Inputs> <Outputs> <Output id="2164" points="1009 219" /> <Output id="5164" points="1052 293" /> </Outputs> <Catalysts> <Catalyst id="5162" points="941 330" /> </Catalysts> <Properties> <displayName>HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="8557" reactomeId="8875071" points="256 454, 256 419, 256 388" position="256 419" lineWidth="1.0"> <Inputs> <Input id="8558" points="281 469" /> <Input id="8559" points="256 493" /> <Input id="8562" points="234 466" /> </Inputs> <Outputs> <Output id="261" points="256 343" /> <Output id="8765" points="228 376" /> <Output id="8767" points="283 382" /> </Outputs> <Catalysts> <Catalyst id="8560" points="220 419" /> </Catalysts> <Properties> <displayName>ACSS3 ligates CoA to CH3COO-</displayName> </Properties> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process>
width1360
[Change default viewing format]
No pathways have been reviewed or authored by Diagram of Ketone body metabolism (8979166)
Follow Reactome