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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Details on Person Diagram of Fatty acyl-CoA biosynthesis

Class:IdPathwayDiagram:8978876
_displayNameDiagram of Fatty acyl-CoA biosynthesis
_timestamp2024-04-10 21:58:50
created[InstanceEdit:8978877] D'Eustachio, Peter, 2017-02-20
height1654
modified[InstanceEdit:8978914] D'Eustachio, Peter, 2017-02-20
[InstanceEdit:8978918] D'Eustachio, Peter, 2017-02-20
[InstanceEdit:8979080] D'Eustachio, Peter, 2017-02-21
[InstanceEdit:8979195] D'Eustachio, Peter, 2017-02-22
[InstanceEdit:8981175] Matthews, Lisa, 2017-03-03
[InstanceEdit:9645116] Wu, G, 2019-05-03
[InstanceEdit:9734536] Jassal, Bijay, 2021-06-17
[InstanceEdit:9735490] Jassal, Bijay, 2021-06-29
[InstanceEdit:9735711] Jassal, Bijay, 2021-06-30
[InstanceEdit:9820478] D'Eustachio, Peter, 2022-11-07
[InstanceEdit:9854267] Stephan, Ralf, 2023-11-24
[InstanceEdit:9854269] Stephan, Ralf, 2023-11-24
[InstanceEdit:9865851] D'Eustachio, Peter, 2024-03-19
[InstanceEdit:9865937] D'Eustachio, Peter, 2024-03-20
[InstanceEdit:9865949] D'Eustachio, Peter, 2024-03-20
[InstanceEdit:9907496] D'Eustachio, Peter, 2024-04-10
representedPathway[Pathway:75105] Fatty acyl-CoA biosynthesis [Homo sapiens]
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43 31" textPosition="277 1031"> <Properties> <displayName>H2O</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="4572" reactomeId="5690516" position="481 1060" bounds="457 1045 48 31" textPosition="461 1049" /> <org.gk.render.RenderableProtein id="4573" reactomeId="5690068" position="360 1030" bounds="341 1019 39 23" textPosition="341 1019"> <Properties> <displayName>PPT1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="4575" reactomeId="1605715" position="664 1088" bounds="643 1073 43 31" textPosition="647 1077" /> <org.gk.render.RenderableChemical id="4576" reactomeId="5690537" position="686 1021" bounds="649 1006 75 31" textPosition="652 1010" /> <org.gk.render.RenderableChemical id="4577" reactomeId="1678675" position="524 1110" bounds="495 1095 59 31" textPosition="498 1099" /> <org.gk.render.RenderableProtein id="4578" reactomeId="5690039" position="581 1006" bounds="562 995 39 23" textPosition="562 995"> <Properties> <displayName>PPT2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableCompartment id="4579" reactomeId="161320" position="487 1051" bounds="222 957 530 189" textPosition="236 973" bgColor="250 240 240" lineColor="255 153 102" insets="232 967 509 171"> <Properties> <displayName>lysosomal lumen</displayName> </Properties> <Components> <Component id="4572" /> <Component id="4577" /> <Component id="4578" /> <Component id="4576" /> <Component id="4575" /> <Component id="4569" /> <Component id="4570" /> <Component id="4573" /> <Component id="5152" /> <Component id="9198" /> <Component id="9200" /> <Component id="9310" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableChemical id="5143" reactomeId="4085415" position="1445 1459" bounds="1406 1444 78 31" textPosition="1409 1448"> <Properties> <displayName>Fe(2+)Cb5</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="5144" reactomeId="29356" position="1471 1562" bounds="1450 1547 43 31" textPosition="1454 1551" /> <org.gk.render.RenderableChemical id="5145" reactomeId="5690558" position="1493 1605" bounds="1460 1590 66 31" textPosition="1463 1594"> <Properties> <displayName>OLE-CoA</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="5146" reactomeId="4085425" position="1448 1517" bounds="1409 1502 78 31" textPosition="1412 1506"> <Properties> <displayName>Fe(3+)Cb5</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="5149" reactomeId="70106" position="1432 1423" bounds="1415 1408 34 31" textPosition="1418 1412" /> <org.gk.render.RenderableChemical id="5151" reactomeId="29368" position="1463 1393" bounds="1446 1378 34 31" textPosition="1450 1382"> <Properties> <displayName>O2</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="5152" reactomeId="6785219" position="438 1110" bounds="409 1095 58 31" textPosition="413 1099"> <Properties> <displayName>protein</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="5908" reactomeId="8847584" position="1636 1443" bounds="1597 1432 78 23" textPosition="1597 1433" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SCD5 dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="5909" reactomeId="8854942" position="1638 1489" bounds="1603 1478 70 23" textPosition="1603 1479" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>SCD dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="9098" reactomeId="5216184" position="362 395" bounds="332 384 61 23" textPosition="332 384"> <Properties> <displayName>SLC27A3</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="9162" reactomeId="8933313" position="976 328" bounds="950 317 52 23" textPosition="950 317"> <Properties> <displayName>MORC2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="9173" reactomeId="29508" position="1385 750" bounds="1353 735 64 31" textPosition="1356 739"> <Properties> <displayName>Mal-CoA</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="9202" reactomeId="8862377" position="206 625" bounds="172 610 69 31" textPosition="175 614"> <Properties> <displayName>3OA-ACP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="9203" reactomeId="113600" position="239 587" bounds="210 572 59 31" textPosition="214 576" /> <org.gk.render.RenderableChemical id="9204" reactomeId="113529" position="250 654" bounds="233 639 34 31" textPosition="236 643" /> <org.gk.render.RenderableChemical id="9205" reactomeId="113563" position="428 587" bounds="399 572 58 31" textPosition="402 576" /> <org.gk.render.RenderableChemical id="9206" reactomeId="8862371" position="454 625" bounds="420 610 69 31" textPosition="423 614"> <Properties> <displayName>3HA-ACP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="9207" reactomeId="8862181" position="335 566" bounds="271 555 129 23" textPosition="271 556" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>2xHSD17B8:2xCBR4</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableChemical id="9209" reactomeId="8957387" position="253 735" bounds="219 720 69 31" textPosition="222 724"> <Properties> <displayName>3HA-CoA</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="9210" reactomeId="8957386" position="461 735" bounds="430 720 63 31" textPosition="433 724"> <Properties> <displayName>t2E-CoA</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="9211" reactomeId="113521" position="423 774" bounds="402 759 43 31" textPosition="406 763" /> <org.gk.render.RenderableProtein id="9212" reactomeId="8933306" position="333 685" bounds="312 674 43 23" textPosition="312 674"> <Properties> <displayName>HTD2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.ProcessNode id="9249" reactomeId="191273" position="1206 181" bounds="1148 155 116 52" textPosition="1163 159"> <Properties> <displayName>Cholesterol biosynthesis</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableCompartment id="9254" reactomeId="17957" position="226 218" bounds="121 156 211 124" textPosition="132 167" bgColor="250 240 240" lineColor="255 153 102" insets="130 164 194 108"> <Components> <Component id="9259" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableChemical id="9256" reactomeId="113592" position="359 188" bounds="339 173 40 31" textPosition="343 177" /> <org.gk.render.RenderableChemicalDrug id="9257" reactomeId="9734538" position="413 164" bounds="376 146 74 36" textPosition="375 146" bgColor="184 154 230" fgColor="161 1 2" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>bempedoic acid</displayName> </Properties> </org.gk.render.RenderableChemicalDrug> <org.gk.render.RenderableChemicalDrug id="9258" reactomeId="9734541" position="583 207" bounds="532 192 103 31" textPosition="533 196" bgColor="184 154 230" fgColor="161 1 2" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>ETC-1002-CoA</displayName> </Properties> </org.gk.render.RenderableChemicalDrug> <org.gk.render.RenderableProtein id="9259" reactomeId="193386" position="323 236" bounds="293 225 61 23" textPosition="293 225"> <Properties> <displayName>SLC27A2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="9261" reactomeId="76194" position="488 191" bounds="459 176 59 31" textPosition="462 180" /> <org.gk.render.RenderableChemical id="9263" reactomeId="76577" position="535 278" bounds="514 263 42 31" textPosition="518 267" /> <org.gk.render.RenderableChemical id="9265" reactomeId="111294" position="476 285" bounds="459 270 34 31" textPosition="463 274" /> <org.gk.render.RenderableComplex id="9268" reactomeId="9734534" position="800 202" bounds="742 185 116 35" textPosition="750 184" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true" hideComponents="true"> <Properties> <displayName>ACLY tetramer:ETC-1002-CoA</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.ProcessNode id="9269" reactomeId="425393" position="667 397" bounds="594 357 147 80" textPosition="594 361"> <Properties> <displayName>Transport of inorganic cations/anions and amino acids/oligopeptides</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableChemical id="9275" reactomeId="70106" position="1493 241" bounds="1476 226 34 31" textPosition="1479 230"> <Properties> <displayName>H+</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="9277" reactomeId="70106" position="1059 565" bounds="1042 550 34 31" textPosition="1045 554" /> <org.gk.render.RenderableChemical id="9285" reactomeId="70106" position="1379 790" bounds="1362 775 34 31" textPosition="1365 779" /> <org.gk.render.RenderableChemical id="9288" reactomeId="70106" position="1833 1033" bounds="1816 1018 34 31" textPosition="1819 1022" /> <org.gk.render.RenderableChemical id="9292" reactomeId="70106" position="1833 655" bounds="1816 640 34 31" textPosition="1819 644" /> <org.gk.render.RenderableChemical id="9298" reactomeId="70106" position="1833 830" bounds="1816 815 34 31" textPosition="1819 819" /> <org.gk.render.RenderableChemical id="9310" reactomeId="428040" position="478 1010" bounds="460 995 36 31" textPosition="464 999" /> </Nodes> <Edges> <org.gk.render.RenderableReaction id="303" reactomeId="75848" points="916 272, 976 272, 1010 272" position="976 272" lineWidth="1.0"> <Inputs> <Input id="18" points="908 293" /> <Input id="19" points="849 272" /> <Input id="20" points="903 261" /> </Inputs> <Outputs> <Output id="21" points="1048 294" /> <Output id="22" points="1049 325" /> <Output id="23" points="1083 272" /> <Output id="24" points="1064 239" /> </Outputs> <Catalysts> <Catalyst id="25" points="976 222" /> </Catalysts> <Activators> <Activator id="9162" points="976 314" /> </Activators> <Properties> <displayName>ACLY tetramer transforms CIT to Ac-CoA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="304" reactomeId="200555" points="1348 272, 1376 272, 1403 271" position="1376 272" lineWidth="1.0"> <Inputs> <Input id="26" points="1323 285" /> <Input id="27" points="1327 251" /> <Input id="23" points="1147 272" /> </Inputs> <Outputs> <Output id="29" points="1557 271" /> <Output id="30" points="1421 289" /> <Output id="28" points="1419 246" /> <Output id="9275" points="1473 246" /> </Outputs> <Catalysts> <Catalyst id="392" points="1376 333" /> </Catalysts> <Activators> <Activator id="19" points="833 291, 864 382, 1284 382" /> </Activators> <Properties> <displayName>Formation of Malonyl-CoA from Acetyl-CoA (liver)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="305" reactomeId="163756" points="1810 402, 1751 402, 1708 402" position="1751 402" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="32" stoichiometry="2" /> </Inputs> <Outputs> <Output id="33" /> </Outputs> <Catalysts> <Catalyst id="32" points="1810 396, 1751 375" /> </Catalysts> <Properties> <displayName>Formation of fatty acid synthase (FAS) dimer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="306" reactomeId="75872" points="1594 369, 1595 404, 1594 438" position="1595 404" lineWidth="1.0"> <Inputs> <Input id="34" stoichiometry="14" points="1634 356" /> <Input id="35" stoichiometry="14" points="1615 335" /> <Input id="29" stoichiometry="7" points="1592 291" /> <Input id="2157" points="1547 342" /> </Inputs> <Outputs> <Output id="2155" stoichiometry="6" points="1661 441" /> <Output id="39" stoichiometry="7" points="1536 410" /> <Output id="2154" points="1595 483" /> <Output id="36" stoichiometry="14" points="1640 463" /> <Output id="46" stoichiometry="8" points="1555 452" /> </Outputs> <Catalysts> <Catalyst id="33" points="1626 403" /> </Catalysts> <Properties> <displayName>Conversion of malonyl-CoA and acetyl-CoA to palmitate</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="307" reactomeId="201035" points="1568 564, 1568 645, 1568 685" position="1568 645" lineWidth="1.0"> <Inputs> <Input id="2153" points="1532 554" /> <Input id="2154" points="1583 520, 1568 536" /> <Input id="2161" points="1526 527" /> </Inputs> <Outputs> <Output id="41" points="1477 698" /> <Output id="42" points="1579 720" /> <Output id="43" points="1511 670" /> <Output id="44" points="1517 722" /> </Outputs> <Catalysts> <Catalyst id="399" points="1605 643" /> </Catalysts> <Properties> <displayName>ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="311" reactomeId="548843" points="1883 528, 1883 556, 1883 582" position="1883 556" lineWidth="1.0"> <Inputs> <Input id="50" points="1911 530" /> <Input id="51" points="1885 485" /> <Input id="57" points="1917 510" /> </Inputs> <Outputs> <Output id="52" points="1885 612" /> <Output id="53" points="1963 551" /> <Output id="55" points="1963 582" /> <Output id="56" points="1925 602" /> </Outputs> <Catalysts> <Catalyst id="393" points="1806 556" /> </Catalysts> <Properties> <displayName>ACSL3,4 ligate CoA to AA to form AA-CoA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="312" reactomeId="548814" points="1496 783, 1496 814, 1496 851" position="1496 814" lineWidth="1.0"> <Inputs> <Input id="44" points="1497 759" /> <Input id="9173" points="1420 759" /> <Input id="9285" points="1399 788" /> </Inputs> <Outputs> <Output id="58" points="1497 888" /> <Output id="60" points="1465 866" /> <Output id="61" points="1530 868" /> </Outputs> <Catalysts> <Catalyst id="569" points="1598 813" /> </Catalysts> <Properties> <displayName>ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="316" reactomeId="548800" points="1885 670, 1886 693, 1888 715" position="1886 693" lineWidth="1.0"> <Inputs> <Input id="52" points="1885 649" /> <Input id="29" points="1627 280, 2014 389, 2019 626" /> <Input id="9292" points="1853 659" /> </Inputs> <Outputs> <Output id="65" points="1886 739" /> <Output id="67" points="1950 748" /> <Output id="68" points="1960 718" /> </Outputs> <Catalysts> <Catalyst id="1434" points="1806 688" /> </Catalysts> <Properties> <displayName>ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="317" reactomeId="548815" points="1888 859, 1889 891, 1888 922" position="1889 891" lineWidth="1.0"> <Inputs> <Input id="69" points="1886 831" /> <Input id="29" points="1627 279, 2032 370, 2033 811" /> <Input id="9298" points="1853 838" /> </Inputs> <Outputs> <Output id="70" points="1886 948" /> <Output id="72" points="1950 912" /> <Output id="73" points="1944 943" /> </Outputs> <Catalysts> <Catalyst id="1332" points="1808 892" /> </Catalysts> <Properties> <displayName>ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="318" reactomeId="548830" points="1884 1053, 1883 1083, 1885 1115" position="1883 1083" lineWidth="1.0"> <Inputs> <Input id="74" points="1885 1030" /> <Input id="29" points="1627 277, 2050 357, 2050 1017" /> <Input id="9288" points="1853 1039" /> </Inputs> <Outputs> <Output id="75" points="1885 1148" /> <Output id="77" points="1935 1129" /> <Output id="78" points="1941 1100" /> </Outputs> <Catalysts> <Catalyst id="1736" points="1811 1080" /> </Catalysts> <Properties> <displayName>ELOVL1,4 elongate TCS-CoA and Mal-CoA to 3OHC-CoA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="319" reactomeId="548818" points="1499 957, 1499 983, 1499 1009" position="1499 983" lineWidth="1.0"> <Inputs> <Input id="58" points="1498 925" /> <Input id="81" points="1477 946" /> <Input id="82" points="1527 944" /> </Inputs> <Outputs> <Output id="79" points="1499 1031" /> <Output id="83" points="1472 1013" /> </Outputs> <Catalysts> <Catalyst id="403" points="1585 985" /> </Catalysts> <Properties> <displayName>HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="321" reactomeId="548831" points="1504 1281, 1505 1301, 1505 1320" position="1505 1301" lineWidth="1.0"> <Inputs> <Input id="85" points="1504 1257" /> <Input id="89" points="1466 1270" /> <Input id="90" points="1551 1260" /> </Inputs> <Outputs> <Output id="87" points="1505 1346" /> <Output id="91" points="1467 1325" /> </Outputs> <Catalysts> <Catalyst id="404" points="1587 1298" /> </Catalysts> <Properties> <displayName>TECR,TECRL dehydrogenate TOD-CoA to ST-CoA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="410" reactomeId="5655955" points="1190 516, 1154 516, 1109 515" position="1154 516" lineWidth="1.0"> <Inputs> <Input id="411" stoichiometry="2" points="1223 539" /> <Input id="412" points="1228 497" /> </Inputs> <Outputs> <Output id="413" stoichiometry="2" points="1054 515" /> <Output id="416" points="1074 492" /> <Output id="9277" stoichiometry="2" points="1074 547" /> </Outputs> <Catalysts> <Catalyst id="414" points="1154 480" /> </Catalysts> <Properties> <displayName>OLAH hydrolyzes decanoyl-FASN dimer to DECA and FASN dimer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2031" reactomeId="5676637" points="1502 1111, 1502 1136, 1502 1159" position="1502 1136" lineWidth="1.0"> <Inputs> <Input id="2032" /> </Inputs> <Outputs> <Output id="2033" points="1475 1162" /> <Output id="2034" points="1502 1179" /> </Outputs> <Catalysts> <Catalyst id="2035" points="1611 1135" /> </Catalysts> <Properties> <displayName>PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="2277" reactomeId="5695957" points="1454 550, 1454 593, 1454 634" position="1454 593" lineWidth="1.0"> <Inputs> <Input id="2278" points="1432 518" /> <Input id="2161" points="1489 527" /> <Input id="2153" points="1486 550" /> </Inputs> <Outputs> <Output id="41" points="1453 684" /> <Output id="43" points="1471 651" /> <Output id="2280" points="1422 644" /> </Outputs> <Catalysts> <Catalyst id="2281" points="1411 591" /> </Catalysts> <Properties> <displayName>ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="3778" reactomeId="5696007" points="295 471, 362 469, 410 469" position="362 469" lineWidth="1.0"> <Inputs> <Input id="3779" points="251 463" /> <Input id="3780" points="272 440" /> <Input id="3786" points="289 491" /> </Inputs> <Outputs> <Output id="3781" points="460 440" /> <Output id="3782" points="495 469" /> <Output id="3783" points="448 497" /> </Outputs> <Catalysts> <Catalyst id="3784" points="362 490" /> </Catalysts> <Properties> <displayName>ACSF3 ligates CoA-SH to VLCFA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="5142" reactomeId="5690565" points="1343 1401, 1342 1460, 1342 1515" position="1342 1460" lineWidth="1.0"> <Inputs> <Input id="87" points="1473 1370" /> <Input id="5143" stoichiometry="2" points="1417 1441" /> <Input id="5149" stoichiometry="2" points="1412 1418" /> <Input id="5151" points="1443 1394" /> </Inputs> <Outputs> <Output id="5144" stoichiometry="2" points="1447 1554" /> <Output id="5145" points="1466 1587" /> <Output id="5146" stoichiometry="2" points="1406 1516" /> </Outputs> <Catalysts> <Catalyst id="5909" points="1600 1488, 1385 1485" /> </Catalysts> <Properties> <displayName>SCD desaturates ST-CoA to OLE-CoA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="5906" reactomeId="8847579" points="1541 1404, 1541 1439, 1541 1508" position="1541 1439" lineWidth="1.0"> <Inputs> <Input id="87" points="1518 1383" /> <Input id="5143" stoichiometry="2" points="1472 1441" /> <Input id="5151" points="1483 1395" /> <Input id="5149" stoichiometry="2" points="1452 1420" /> </Inputs> <Outputs> <Output id="5145" points="1500 1587" /> <Output id="5146" stoichiometry="2" points="1490 1513" /> <Output id="5144" stoichiometry="2" points="1491 1544" /> </Outputs> <Catalysts> <Catalyst id="5908" points="1594 1441" /> </Catalysts> <Properties> <displayName>SCD5 desaturates ST-CoA to OLE-CoA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="9096" reactomeId="8875077" points="336 439, 362 438, 405 439" position="362 438" lineWidth="1.0"> <Inputs> <Input id="3780" points="293 427" /> <Input id="3786" points="296 491" /> <Input id="3779" points="251 456" /> </Inputs> <Outputs> <Output id="3781" points="442 430" /> <Output id="3782" points="495 464" /> <Output id="3783" points="457 494" /> </Outputs> <Catalysts> <Catalyst id="9098" points="362 410" /> </Catalysts> <Properties> <displayName>SLC27A3 ligates CoA-SH to VLCFA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="9198" reactomeId="5690517" points="322 1074, 361 1075, 393 1075" position="361 1075" lineWidth="1.0"> <Inputs> <Input id="4569" points="303 1093" /> <Input id="4570" points="307 1061" /> </Inputs> <Outputs> <Output id="5152" points="418 1092" /> <Output id="9310" points="457 1023" /> <Output id="4572" points="454 1064" /> </Outputs> <Catalysts> <Catalyst id="4573" points="360 1045" /> </Catalysts> <Properties> <displayName>PPT1 hydrolyses palmitoylated proteins</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="9200" reactomeId="5690046" points="623 1060, 582 1060, 545 1060" position="582 1060" lineWidth="1.0"> <Inputs> <Input id="4576" points="660 1040" /> <Input id="4575" points="640 1073" /> </Inputs> <Outputs> <Output id="9310" points="499 1023" /> <Output id="4577" points="530 1092" /> <Output id="4572" points="508 1060" /> </Outputs> <Catalysts> <Catalyst id="4578" points="581 1021" /> </Catalysts> <Properties> <displayName>PPT2 hydrolyses PALMCoA to PALM</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="9201" reactomeId="8862152" points="305 624, 337 624, 377 624" position="337 624" lineWidth="1.0"> <Inputs> <Input id="9202" points="244 624" /> <Input id="9203" points="266 606" /> <Input id="9204" points="270 644" /> </Inputs> <Outputs> <Output id="9205" points="406 606" /> <Output id="9206" points="417 624" /> </Outputs> <Catalysts> <Catalyst id="9207" points="335 581" /> </Catalysts> <Properties> <displayName>2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="9208" reactomeId="8957389" points="291 735, 333 735, 377 735" position="333 735" lineWidth="1.0"> <Inputs> <Input id="9209" /> </Inputs> <Outputs> <Output id="9210" points="427 735" /> <Output id="9211" points="404 756" /> </Outputs> <Catalysts> <Catalyst id="9212" points="333 700" /> </Catalysts> <Properties> <displayName>RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="9250" interactionType="Activate" points="1131 254, 1179 210" position="1155 232" lineWidth="2.0"> <Inputs> <Input id="23" /> </Inputs> <Outputs> <Output id="9249" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="9255" reactomeId="9734535" points="412 214, 412 239, 471 239" position="412 239" lineWidth="1.0"> <Inputs> <Input id="9256" points="382 197" /> <Input id="9257" points="412 185" /> <Input id="9261" points="456 199" /> </Inputs> <Outputs> <Output id="9258" points="529 221" /> <Output id="9263" points="511 265" /> <Output id="9265" points="474 267" /> </Outputs> <Catalysts> <Catalyst id="9259" points="357 237" /> </Catalysts> <Properties> <displayName>SLC27A2 ligates CoA to bempedoic acid to form ETC-1002-CoA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="9267" reactomeId="9734540" points="801 146, 800 146, 800 182" position="800 146" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="9258" points="638 192" /> <Input id="25" points="943 193" /> </Inputs> <Outputs> <Output id="9268" /> </Outputs> <Properties> <displayName>ACLY tetramer binds ETC-1002-CoA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="9270" interactionType="Activate" points="717 354, 807 285" position="762 319" lineWidth="2.0"> <Inputs> <Input id="9269" /> </Inputs> <Outputs> <Output id="19" /> </Outputs> </org.gk.render.RenderableInteraction> </Edges> <Pathways /> </Process>
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No pathways have been reviewed or authored by Diagram of Fatty acyl-CoA biosynthesis (8978876)
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