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Details on Person UniProt:Q14241 ELOA
| Class:Id | ReferenceGeneProduct:89784 |
|---|---|
| _chainChangeLog | chain:1-798 added on Fri February 6 2015;chain:1-798 for 89784 removed on Mon Feb 26 2024;chain:1-772 for 89784 added on Mon Feb 26 2024 |
| _displayName | UniProt:Q14241 ELOA |
| _timestamp | 2024-11-03 20:09:49 |
| chain | chain:1-772 |
| checksum | 0D2C93B1D54EB09A |
| comment | FUNCTION SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).FUNCTION As part of a multisubunit complex composed of elongin BC complex (ELOB and ELOC), elongin A/ELOA, RBX1 and CUL5; polyubiquitinates monoubiquitinated POLR2A.SUBUNIT Heterotrimer of an A (ELOA, ELOA2 or ELOA3P), ELOB and ELOC subunit (By similarity). Part of a multisubunit ubiquitin ligase complex consisting of elongin BC complex (ELOB and ELOC), elongin A/ELOA, RBX1 and CUL5 (PubMed:19920177). Interacts with ERCC6; the interaction is induced by DNA damaging agents or inhibitors of RNA polymerase II elongation (By similarity). Interacts (via BC-box) with CUL5 (By similarity).INTERACTION Localizes to sites of DNA damage.ALTERNATIVE PRODUCTS The BC-box, which mediates binding to the elongin BC complex, has the consensus sequence [APST]-L-x(3)-C-x(3)-[AILV].MISCELLANEOUS Produced by alternative initiation (Probable). Based on proteomic data (Probable).SEQUENCE CAUTION Truncated N-terminus. |
| description | recommendedName: fullName evidence="9"Elongin-A shortName: EloA alternativeName: Elongin 110 kDa subunit alternativeName: RNA polymerase II transcription factor SIII subunit A1 alternativeName: SIII p110 alternativeName: Transcription elongation factor B polypeptide 3 |
| geneName | ELOA TCEB3 MSTP059 |
| identifier | Q14241 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative initiation Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | ELOA |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002326] ENSEMBL:ENSG00000011007 ELOA [Homo sapiens] |
| secondaryIdentifier | ELOA1_HUMAN B2R7Q8 Q8IXH1 |
| sequenceLength | 772 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:9862235] Unknown:Q14241-2 ELOA [Homo sapiens] [ReferenceIsoform:9862236] Unknown:Q14241-1 ELOA [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:112421] TCEB3 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q14241 ELOA (89784)
