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Details on Person UniProt:Q9P2U7-1 SLC17A7
| Class:Id | ReferenceIsoform:8978120 |
|---|---|
| _chainChangeLog | chain:1-560 added on Fri February 17 2017 |
| _displayName | UniProt:Q9P2U7-1 SLC17A7 |
| _timestamp | 2025-02-21 20:05:20 |
| chain | chain:1-560 |
| checksum | C88DAFB34B6E45B6 |
| comment | FUNCTION Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, proton, potassium, sodium and phosphate (PubMed:10820226). At the synaptic vesicle membrane, mainly functions as an uniporter which transports preferentially L-glutamate but also phosphate from the cytoplasm into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells (By similarity). The L-glutamate or phosphate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H(+)-ATPase across the synaptic vesicle membrane (By similarity). In addition, functions as a chloride channel that allows a chloride permeation through the synaptic vesicle membrane that affects the proton electrochemical gradient and promotes synaptic vesicles acidification (By similarity). Moreover, may function as a K(+)/H(+) antiport allowing to maintain the electrical gradient and to decrease chemical gradient and therefore sustain vesicular glutamate uptake (By similarity). The vesicular K(+)/H(+) antiport activity is electroneutral (By similarity). At the plasma membrane, following exocytosis, functions as a symporter of Na(+) and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation (PubMed:10820226). The symporter activity is driven by an inside negative membrane potential and is electrogenic (By similarity). Is necessary for synaptic signaling of visual-evoked responses from photoreceptors (By similarity).CATALYTIC ACTIVITY L-glutamate(out) = L-glutamate(in)CATALYTIC ACTIVITY chloride(in) = chloride(out)CATALYTIC ACTIVITY 3 Na(+)(out) + phosphate(out) = 3 Na(+)(in) + phosphate(in)CATALYTIC ACTIVITY phosphate(in) = phosphate(out)CATALYTIC ACTIVITY K(+)(in) + H(+)(out) = K(+)(out) + H(+)(in)ACTIVITY REGULATION Chloride channel activity is allosterically activated by lumenal H(+) and Cl(-) leading to synaptic vesicles acidification. The L-glutamate transport activity is allosterically activated by lumenal H(+) and Cl(-). The allosteric activation by H(+) efficiently prevents non-vesicular efflux across the plasma membrane, thereby restricting L-glutamate transport activity to acidic membranes such as synaptic vesicles.SUBUNIT Interacts with SHANK3.SUBCELLULAR LOCATION Expressed in several regions of the brain including amygdala, cerebellum, cerebral cortex, hippocampus, frontal lobe, medulla, occipital lobe, putamen and temporal lobe.SIMILARITY Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.CAUTION Martineau M. et al. show that may function as a L-glutamate/H(+) antiporter (By similarity). However, according to Eriksen J. et al., H(+) is an allosteric activator (By similarity). |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: fullName evidence="1"Vesicular glutamate transporter 1 shortName evidence="1"VGluT1 alternativeName: fullName evidence="7"Brain-specific Na(+)-dependent inorganic phosphate cotransporter alternativeName: Solute carrier family 17 member 7 |
| geneName | SLC17A7 BNPI VGLUT1 |
| identifier | Q9P2U7 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Antiport Cell membrane Chloride Chloride channel Cytoplasmic vesicle Ion channel Ion transport Membrane Neurotransmitter transport Phosphate transport Phosphoprotein Proteomics identification Reference proteome Sodium Sodium transport Symport Synapse Synaptosome Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | SLC17A7 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8988753] ENSEMBL:ENSG00000104888 SLC17A7 [Homo sapiens] |
| secondaryIdentifier | VGLU1_HUMAN B4DFR9 B4DG46 Q6PCD0 |
| sequenceLength | 560 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q9P2U7-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9P2U7-1 SLC17A7 (8978120)
