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Details on Person UniProt:P23759-3 PAX7
| Class:Id | ReferenceIsoform:8977966 |
|---|---|
| _chainChangeLog | chain:1-505 added on Fri February 17 2017 |
| _displayName | UniProt:P23759-3 PAX7 |
| _timestamp | 2024-11-03 19:47:47 |
| chain | chain:1-505 |
| checksum | E51CF8B3E8D4C3D9 |
| comment | FUNCTION Transcription factor that is involved in the regulation of muscle stem cells proliferation, playing a role in myogenesis and muscle regeneration.SUBUNIT Can bind to DNA as a heterodimer with PAX3. Interacts with PAXBP1; the interaction links PAX7 to a WDR5-containing histone methyltransferase complex (By similarity). Interacts with DAXX (PubMed:10393185).INTERACTION Acetylation at Lys-105 and Lys-139 by KAT8 is required for high-level transcription factor activity. Deacetylated by SIRT2.DISEASE The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving PAX7 is found in rhabdomyosarcoma. Translocation t(1;13)(p36;q14) with FOXO1. The resulting protein is a transcriptional activator.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the paired homeobox family. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: Paired box protein Pax-7 alternativeName: HuP1 |
| geneName | PAX7 HUP1 |
| identifier | P23759 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Acetylation Alternative splicing Chromosomal rearrangement Developmental protein Disease variant DNA-binding Homeobox Myogenesis Nucleus Paired box Proteomics identification Proto-oncogene Reference proteome Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | PAX7 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996780] ENSEMBL:ENSG00000009709 PAX7 [Homo sapiens] |
| secondaryIdentifier | PAX7_HUMAN E9PFV9 Q0VA99 Q2PJS5 |
| sequenceLength | 505 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P23759-3 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P23759-3 PAX7 (8977966)
