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Details on Person UniProt:O94776-2 MTA2
| Class:Id | ReferenceIsoform:8977944 |
|---|---|
| _chainChangeLog | chain:1-668 added on Fri February 17 2017 |
| _displayName | UniProt:O94776-2 MTA2 |
| _timestamp | 2025-08-15 21:39:31 |
| chain | chain:1-668 |
| checksum | 65087AF798BA64EC |
| comment | FUNCTION May function as a transcriptional coregulator (PubMed:16428440, PubMed:28977666). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666).SUBUNIT Component of the nucleosome remodeling and deacetylase (NuRD) repressor complex, composed of core proteins MTA1, MTA2, MTA3, RBBP4, RBBP7, HDAC1, HDAC2, MBD2, MBD3, and peripherally associated proteins CDK2AP1, CDK2AP2, GATAD2A, GATAD2B, CHD3, CHD4 and CHD5 (PubMed:16428440, PubMed:28977666, PubMed:33283408). The exact stoichiometry of the NuRD complex is unknown, and some subunits such as MBD2 and MBD3, GATAD2A and GATAD2B, and CHD3, CHD4 and CHD5 define mutually exclusive NuRD complexes (PubMed:16428440, PubMed:28977666, PubMed:33283408). Interacts with CHD3 (PubMed:28977666). Interacts with CHD4 (PubMed:28977666). Interacts with GATAD2A (PubMed:33283408). Interacts with HDAC7 (By similarity). Interacts with MBD3 (By similarity). Interacts with p53/TP53 (PubMed:11099047). Interacts with MINT (PubMed:11331609). Interacts with PIMREG (PubMed:18757745). Interacts with NACC2 (PubMed:22926524). Interacts with ERCC6 (PubMed:26030138). Interacts with PWWP2B (By similarity). Interacts with transcription factor BCL11A (PubMed:39423807).INTERACTION Widely expressed.SIMILARITY Belongs to the metastasis-associated protein family.SEQUENCE CAUTION Contaminating sequence. Potential poly-A sequence. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: Metastasis-associated protein MTA2 alternativeName: Metastasis-associated 1-like 1 shortName: MTA1-L1 protein alternativeName: p53 target protein in deacetylase complex |
| geneName | MTA2 MTA1L1 PID |
| identifier | O94776 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Acetylation Alternative splicing DNA-binding Isopeptide bond Metal-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Ubl conjugation Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | MTA2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8991983] ENSEMBL:ENSG00000149480 MTA2 [Homo sapiens] |
| secondaryIdentifier | MTA2_HUMAN Q68DB1 Q9UQB5 |
| sequenceLength | 668 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | O94776-2 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O94776-2 MTA2 (8977944)
