Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q13601-1 KRR1
| Class:Id | ReferenceIsoform:8977895 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 17 2017;chain:2-381 added on Fri February 17 2017;initiator methionine:1 for 8977895 removed on Fri Nov 03 2023;initiator methionine: for 8977895 added on Fri Nov 03 2023;initiator methionine: for 8977895 removed on Fri Aug 15 2025;initiator methionine:1 for 8977895 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q13601-1 KRR1 |
| _timestamp | 2025-08-15 21:08:20 |
| chain | initiator methionine:1 chain:2-381 |
| checksum | 8F242FCC36BF079B |
| comment | FUNCTION Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.SUBUNIT Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.SUBUNIT (Microbial infection) Directly interacts with HIV-1 protein VPR. Also identified in a complex with NR3C1 and HIV-1 protein VPR.INTERACTION (Microbial infection) Translocates from cytoplasm to nucleus after exposure to HIV-1 virus or HIV-1 protein VPR or induction by hydrocortisone and dexamethasone in the absence of HIV-1 protein VPR.ALTERNATIVE PRODUCTS Belongs to the KRR1 family.SEQUENCE CAUTION Contaminating sequence. Potential poly-A sequence. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: KRR1 small subunit processome component homolog alternativeName: HIV-1 Rev-binding protein 2 alternativeName: KRR-R motif-containing protein 1 alternativeName: Rev-interacting protein 1 shortName: Rip-1 |
| geneName | KRR1 HRB2 |
| identifier | Q13601 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Cytoplasm Direct protein sequencing Isopeptide bond Nucleus Phosphoprotein Proteomics identification Reference proteome Ribonucleoprotein Ribosome biogenesis RNA-binding rRNA processing Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | KRR1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002429] ENSEMBL:ENSG00000111615 KRR1 [Homo sapiens] |
| secondaryIdentifier | KRR1_HUMAN A0FIK6 A0JLP0 B2R989 E7EUQ0 Q8NEA8 Q8TC37 Q96AT5 |
| sequenceLength | 381 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q13601-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q13601-1 KRR1 (8977895)
