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Details on Person UniProt:O60315-2 ZEB2
| Class:Id | ReferenceIsoform:8977685 |
|---|---|
| _chainChangeLog | chain:1-1214 added on Fri February 17 2017 |
| _displayName | UniProt:O60315-2 ZEB2 |
| _timestamp | 2024-11-03 19:44:20 |
| chain | chain:1-1214 |
| checksum | B578FD91339C3FDD |
| comment | FUNCTION Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters (PubMed:16061479, PubMed:20516212). Represses transcription of E-cadherin (PubMed:16061479). Represses expression of MEOX2 (PubMed:20516212).SUBUNIT Binds activated SMAD1, activated SMAD2 and activated SMAD3; binding with SMAD4 is not detected (By similarity). Interacts with CBX4 and CTBP1.INTERACTION Down-regulated by microRNA-221 (miR-221).PTM Sumoylation on Lys-391 and Lys-866 is promoted by the E3 SUMO-protein ligase CBX4, and impairs interaction with CTBP1 and transcription repression activity.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.SEQUENCE CAUTION Extended N-terminus. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: Zinc finger E-box-binding homeobox 2 alternativeName: fullName evidence="13"Smad-interacting protein 1 shortName evidence="13"SMADIP1 alternativeName: Zinc finger homeobox protein 1b |
| geneName | ZEB2 KIAA0569 SIP1 ZFHX1B ZFX1B HRIHFB2411 |
| identifier | O60315 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Chromosome Disease variant DNA-binding Epilepsy Hirschsprung disease Homeobox Intellectual disability Isopeptide bond Metal-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Repressor Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | ZEB2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8989322] ENSEMBL:ENSG00000169554 ZEB2 [Homo sapiens] |
| secondaryIdentifier | ZEB2_HUMAN A0JP09 B7Z2P2 F5H814 Q9UED1 |
| sequenceLength | 1214 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | O60315-2 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O60315-2 ZEB2 (8977685)
