Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person UniProt:Q92598-4 HSPH1

Class:IdReferenceIsoform:8977445
_chainChangeLoginitiator methionine:1 added on Fri February 17 2017;chain:2-858 added on Fri February 17 2017;initiator methionine:1 for 8977445 removed on Fri Nov 03 2023;initiator methionine: for 8977445 added on Fri Nov 03 2023;initiator methionine: for 8977445 removed on Fri Aug 15 2025;initiator methionine:1 for 8977445 added on Fri Aug 15 2025
_displayNameUniProt:Q92598-4 HSPH1
_timestamp2025-08-15 21:30:44
chaininitiator methionine:1
chain:2-858
checksumD0E757970E340B56
commentFUNCTION Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity).SUBUNIT Interacts with HSPA8/HSC70 (By similarity). Interacts with HSPA1A (via NBD) and HSPA1B (via NBD) (PubMed:24318877).INTERACTION Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells.PTM Phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity.SIMILARITY Belongs to the heat shock protein 70 family.
created[InstanceEdit:8964659] Weiser, JD
descriptionrecommendedName: Heat shock protein 105 kDa alternativeName: Antigen NY-CO-25 alternativeName: Heat shock 110 kDa protein alternativeName: Heat shock protein family H member 1
geneNameHSPH1
HSP105
HSP110
KIAA0201
identifierQ92598
isoformParent
isSequenceChangedFALSE
keyword3D-structure
Acetylation
Alternative splicing
ATP-binding
Cytoplasm
Direct protein sequencing
Nucleotide-binding
Phosphoprotein
Proteomics identification
Reference proteome
Stress response
modified[InstanceEdit:9836292] Weiser, Joel, 2023-05-25
[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
[InstanceEdit:9917590] Weiser, Joel, 2024-08-09
[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
nameHSPH1
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:4793746] ENSEMBL:ENSG00000120694 HSPH1 [Homo sapiens]
secondaryIdentifierHS105_HUMAN
B4DYH1
O95739
Q5TBM6
Q5TBM7
Q5TBM8
Q9UPC4
sequenceLength858
species[Species:48887] Homo sapiens
variantIdentifierQ92598-4
[Change default viewing format]
No pathways have been reviewed or authored by UniProt:Q92598-4 HSPH1 (8977445)
Follow Reactome