Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q9BYE0-2 HES7
| Class:Id | ReferenceIsoform:8977438 |
|---|---|
| _chainChangeLog | chain:1-225 added on Fri February 17 2017 |
| _displayName | UniProt:Q9BYE0-2 HES7 |
| _timestamp | 2024-11-03 20:10:12 |
| chain | chain:1-225 |
| checksum | BDD4EB0D020E2EE9 |
| comment | FUNCTION Transcriptional repressor. Represses transcription from both N box- and E box-containing promoters. May with HES1, cooperatively regulate somite formation in the presomitic mesoderm (PSM). May function as a segmentation clock, which is essential for coordinated somite segmentation (By similarity).SUBUNIT Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.INTERACTION Has a particular type of basic domain which includes a helix-interrupting proline.DOMAIN The C-terminal WRPW motif is a transcriptional repression motif which is necessary for interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.DISEASE The disease is caused by variants affecting the gene represented in this entry. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: Transcription factor HES-7 shortName: hHes7 alternativeName: Class B basic helix-loop-helix protein 37 shortName: bHLHb37 alternativeName: Hairy and enhancer of split 7 alternativeName: bHLH factor Hes7 |
| geneName | HES7 BHLHB37 |
| identifier | Q9BYE0 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Developmental protein Disease variant DNA-binding Dwarfism Nucleus Proteomics identification Reference proteome Repressor Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | HES7 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8999549] ENSEMBL:ENSG00000179111 HES7 [Homo sapiens] |
| secondaryIdentifier | HES7_HUMAN F8VPC9 |
| sequenceLength | 225 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q9BYE0-2 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9BYE0-2 HES7 (8977438)
