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Details on Person UniProt:Q9BYE0-1 HES7
| Class:Id | ReferenceIsoform:8977437 |
|---|---|
| _chainChangeLog | chain:1-225 added on Fri February 17 2017 |
| _displayName | UniProt:Q9BYE0-1 HES7 |
| _timestamp | 2024-11-03 20:10:12 |
| chain | chain:1-225 |
| checksum | BDD4EB0D020E2EE9 |
| comment | FUNCTION Transcriptional repressor. Represses transcription from both N box- and E box-containing promoters. May with HES1, cooperatively regulate somite formation in the presomitic mesoderm (PSM). May function as a segmentation clock, which is essential for coordinated somite segmentation (By similarity).SUBUNIT Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.INTERACTION Has a particular type of basic domain which includes a helix-interrupting proline.DOMAIN The C-terminal WRPW motif is a transcriptional repression motif which is necessary for interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.DISEASE The disease is caused by variants affecting the gene represented in this entry. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: Transcription factor HES-7 shortName: hHes7 alternativeName: Class B basic helix-loop-helix protein 37 shortName: bHLHb37 alternativeName: Hairy and enhancer of split 7 alternativeName: bHLH factor Hes7 |
| geneName | HES7 BHLHB37 |
| identifier | Q9BYE0 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Developmental protein Disease variant DNA-binding Dwarfism Nucleus Proteomics identification Reference proteome Repressor Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | HES7 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8999549] ENSEMBL:ENSG00000179111 HES7 [Homo sapiens] |
| secondaryIdentifier | HES7_HUMAN F8VPC9 |
| sequenceLength | 225 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q9BYE0-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9BYE0-1 HES7 (8977437)
