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Details on Person UniProt:O14576-4 DYNC1I1
| Class:Id | ReferenceIsoform:8977376 |
|---|---|
| _chainChangeLog | chain:1-645 added on Fri February 17 2017;initiator methionine:1 for 8977376 removed on Fri Nov 03 2023;initiator methionine: for 8977376 added on Fri Nov 03 2023;initiator methionine: for 8977376 removed on Fri Aug 15 2025;initiator methionine:1 for 8977376 added on Fri Aug 15 2025 |
| _displayName | UniProt:O14576-4 DYNC1I1 |
| _timestamp | 2025-08-15 21:59:57 |
| chain | initiator methionine:1 chain:2-645 |
| checksum | 55A6FF971E632DA0 |
| comment | FUNCTION Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores.SUBUNIT Homodimer (By similarity). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNC1H1. Interacts with DYNLT1 and DYNLT3. Interacts with DCTN1 (By similarity). Interacts with MCRS1; the interaction is required for the proper distribution of centriolar satellites (PubMed:27263857).INTERACTION Belongs to the dynein intermediate chain family. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: Cytoplasmic dynein 1 intermediate chain 1 alternativeName: Cytoplasmic dynein intermediate chain 1 alternativeName: Dynein intermediate chain 1, cytosolic shortName: DH IC-1 |
| geneName | DYNC1I1 DNCI1 DNCIC1 |
| identifier | O14576 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Acetylation Alternative splicing Centromere Chromosome Cytoplasm Cytoskeleton Dynein Kinetochore Microtubule Motor protein Phosphoprotein Proteomics identification Reference proteome Repeat Transport WD repeat |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | DYNC1I1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8994167] ENSEMBL:ENSG00000158560 DYNC1I1 [Homo sapiens] |
| secondaryIdentifier | DC1I1_HUMAN B4DME3 F5H050 G5E9K1 Q8TBF7 Q9Y2X1 |
| sequenceLength | 645 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | O14576-4 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O14576-4 DYNC1I1 (8977376)
