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Details on Person UniProt:P62633-4 CNBP
| Class:Id | ReferenceIsoform:8977347 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 17 2017;chain:2-177 added on Fri February 17 2017;initiator methionine:1 for 8977347 removed on Fri Nov 03 2023;initiator methionine: for 8977347 added on Fri Nov 03 2023;initiator methionine: for 8977347 removed on Fri Aug 15 2025;initiator methionine:1 for 8977347 added on Fri Aug 15 2025 |
| _displayName | UniProt:P62633-4 CNBP |
| _timestamp | 2025-08-15 21:44:16 |
| chain | initiator methionine:1 chain:2-177 |
| checksum | 996F398285F52618 |
| comment | FUNCTION Single-stranded DNA-binding protein that preferentially binds to the sterol regulatory element (SRE) sequence 5'-GTGCGGTG-3', and thereby mediates transcriptional repression (PubMed:2562787). Has a role as transactivator of the Myc promoter (By similarity). Binds single-stranded RNA in a sequence-specific manner (By similarity).FUNCTION Binds G-rich elements in target mRNA coding sequences (PubMed:28329689). Prevents G-quadruplex structure formation in vitro, suggesting a role in supporting translation by resolving stable structures on mRNAs (PubMed:28329689).FUNCTION Binds to RNA.FUNCTION Binds to RNA.FUNCTION Binds to RNA.FUNCTION Binds to RNA.FUNCTION Binds to RNA.SUBUNIT Associates with the 40S ribosomal subunit, the 80S ribosome and with polysomes.INTERACTION Expressed in the liver, kidney, spleen, testis, lung, muscle and adrenal glands.INDUCTION Transcriptionally up-regulated by sterol treatment.PTM Arginine methylation by PRMT1 in the Arg/Gly-rich region impedes RNA binding.DISEASE The disease is caused by variants affecting the gene represented in this entry. The causative mutation is a CCTG expansion (mean approximately 5000 repeats) located in intron 1 of the CNBP gene. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: fullName evidence="12"CCHC-type zinc finger nucleic acid binding protein alternativeName: fullName evidence="11"Cellular nucleic acid-binding protein shortName evidence="11"CNBP alternativeName: Zinc finger protein 9 |
| geneName | CNBP RNF163 ZNF9 |
| identifier | P62633 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Acetylation Alternative splicing Cytoplasm DNA-binding Endoplasmic reticulum Metal-binding Methylation Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Repressor Transcription Transcription regulation Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | CNBP |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002873] ENSEMBL:ENSG00000169714 CNBP [Homo sapiens] |
| secondaryIdentifier | CNBP_HUMAN A8K7V4 B2RAV9 B4DP17 D3DNB9 D3DNC0 D3DNC1 E9PDR7 P20694 Q4JGY0 Q4JGY1 Q5QJR0 Q5U0E9 Q6PJI7 Q96NV3 |
| sequenceLength | 177 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P62633-4 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P62633-4 CNBP (8977347)
