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Details on Person UniProt:Q99767-2 APBA2
| Class:Id | ReferenceIsoform:8976879 |
|---|---|
| _chainChangeLog | chain:1-749 added on Fri February 17 2017 |
| _displayName | UniProt:Q99767-2 APBA2 |
| _timestamp | 2024-11-03 19:49:55 |
| chain | chain:1-749 |
| checksum | C15AE9CFAEF51D85 |
| comment | FUNCTION Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta.SUBUNIT Part of a multimeric complex containing STXBP1 and syntaxin-1. Binds to the cytoplasmic domain of amyloid-beta protein, and to the nuclear factor NF-kappa-B/p65 via its PDZ domain. Interacts with the N-terminal domain of NECAB3.INTERACTION Brain.DOMAIN Composed of an N-terminal domain that binds STXBP1, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the amyloid-beta precursor protein, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: Amyloid-beta A4 precursor protein-binding family A member 2 alternativeName: Adapter protein X11beta alternativeName: Neuron-specific X11L protein alternativeName: Neuronal Munc18-1-interacting protein 2 shortName: Mint-2 |
| geneName | APBA2 MINT2 X11L |
| identifier | Q99767 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Phosphoprotein Protein transport Proteomics identification Reference proteome Repeat Transport |
| modified | [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9027688] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | APBA2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8995841] ENSEMBL:ENSG00000034053 APBA2 [Homo sapiens] |
| secondaryIdentifier | APBA2_HUMAN E9PGI4 O60571 Q5XKC0 |
| sequenceLength | 749 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q99767-2 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q99767-2 APBA2 (8976879)
