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Details on Person UniProt:P35611-5 ADD1
| Class:Id | ReferenceIsoform:8976865 |
|---|---|
| _chainChangeLog | chain:1-737 added on Fri February 17 2017 |
| _displayName | UniProt:P35611-5 ADD1 |
| _timestamp | 2024-11-03 20:13:07 |
| chain | chain:1-737 |
| checksum | DF13AB30B12F20B6 |
| comment | FUNCTION Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.SUBUNIT Heterodimer of an alpha and a beta subunit or an alpha and a gamma subunit.INTERACTION Additional isoforms seem to exist.TISSUE SPECIFICITY Expressed in all tissues. Found in much higher levels in reticulocytes than the beta subunit.DOMAIN Each subunit is comprised of three regions: a NH2-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region.SIMILARITY Belongs to the aldolase class II family. Adducin subfamily. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: Alpha-adducin alternativeName: Erythrocyte adducin subunit alpha |
| geneName | ADD1 ADDA |
| identifier | P35611 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Acetylation Actin-binding Alternative splicing Calmodulin-binding Cell membrane Cytoplasm Cytoskeleton Direct protein sequencing Membrane Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | ADD1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:5642310] ENSEMBL:ENSG00000087274 ADD1 [Homo sapiens] |
| secondaryIdentifier | ADDA_HUMAN A2A3N8 A2A3P0 B4DI79 D3DVR3 D3DVR4 D3DVR5 Q13734 Q14729 Q16156 Q86XM2 Q9UJB6 |
| sequenceLength | 737 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P35611-5 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P35611-5 ADD1 (8976865)
