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Details on Person UniProt:P30988-6 CALCR
| Class:Id | ReferenceIsoform:8976403 |
|---|---|
| _chainChangeLog | signal peptide:1-42 added on Fri February 17 2017;chain:43-508 added on Fri February 17 2017;signal peptide:1-42 for 8976403 removed on Fri August 9 2019;chain:43-508 for 8976403 removed on Fri August 9 2019;signal peptide:1-24 for 8976403 added on Fri August 9 2019;chain:25-474 for 8976403 added on Fri August 9 2019 |
| _displayName | UniProt:P30988-6 CALCR |
| _timestamp | 2025-02-21 19:04:59 |
| chain | signal peptide:1-24 chain:25-474 |
| checksum | 0D9FA81230B282D9 |
| comment | FUNCTION G protein-coupled receptor activated by ligand peptides amylin (IAPP), calcitonin (CT/CALCA) and calcitonin gene-related peptide type 1 (CGRP1/CALCA) (PubMed:35324283, PubMed:38603770). CALCR interacts with receptor-activity-modifying proteins RAMP1, 2 and 3 to form receptor complexes AMYR1, 2 and 3, respectively (PubMed:35324283, PubMed:38603770). IAPP, CT and CGRP1 activate CALCR and AMYRs with distinct modes of receptor activation resulting in specific phenotypes (PubMed:35324283, PubMed:38603770). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway (PubMed:35324283, PubMed:7476993).FUNCTION Non-functional protein. Unable to couple to G proteins and activate adenylyl cyclase (PubMed:7476993). Does not undergo receptor internalization following ligand binding (PubMed:7476993).ACTIVITY REGULATION Sensitive to cholera toxin.SUBUNIT Heterodimer of CALCR and RAMP1, RAMP2 or RAMP3; the receptor complexes function as AMYR1, AMYR2 and AMYR3 receptors, respectively, and respond to amylin/IAPP, calcitonin/CT and CGRP1 ligands (PubMed:35324283, PubMed:38603770). Interacts with GPRASP2 (PubMed:15086532).SUBCELLULAR LOCATION Genetic variations in CALCR may be correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density, disruption of bone microarchitecture, and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture.SIMILARITY Belongs to the G-protein coupled receptor 2 family. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: fullName evidence="19"Calcitonin receptor shortName: CT-R |
| geneName | CALCR |
| identifier | P30988 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative promoter usage Alternative splicing Cell membrane Direct protein sequencing Disulfide bond G-protein coupled receptor Glycoprotein Membrane Proteomics identification Receptor Reference proteome Signal Transducer Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | CALCR |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001646] ENSEMBL:ENSG00000004948 CALCR [Homo sapiens] |
| secondaryIdentifier | CALCR_HUMAN A0A0C4DG16 A4D1G6 F5H605 O14585 Q13941 Q5ZGL8 Q659U6 Q6DJU8 Q6T712 |
| sequenceLength | 474 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P30988-6 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P30988-6 CALCR (8976403)
