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Details on Person UniProt:P36941-2 LTBR
| Class:Id | ReferenceIsoform:8976290 |
|---|---|
| _chainChangeLog | signal peptide:1-30 added on Fri February 17 2017;chain:31-435 added on Fri February 17 2017 |
| _displayName | UniProt:P36941-2 LTBR |
| _timestamp | 2024-11-03 19:39:23 |
| chain | signal peptide:1-30 chain:31-435 |
| checksum | 624626E6022F656F |
| comment | FUNCTION Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT (PubMed:24248355). Activates NF-kappa-B signaling pathway upon stimulation with lymphotoxin (LTA(1)-LTB(2)) (PubMed:24248355). Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.SUBUNIT Self-associates; dimerization and trimerization are promoted by lymphotoxin (LTA(1)-LTB(2)) (PubMed:29507355). Associates with TRAF3 (PubMed:8663299). Associates with TRAF4 (PubMed:9626059). Associates with TRAF5 (PubMed:9511754). Interacts with Aedes aegypti lymphotoxin beta receptor inhibitor; the interaction reduces dimerization and trimerization of LTBR induced by lymphotoxin (LTA(1)-LTB(2)) (PubMed:29507355, PubMed:38248473).SUBUNIT (Microbial infection) Interacts with HCV core protein. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: Tumor necrosis factor receptor superfamily member 3 alternativeName: Lymphotoxin-beta receptor alternativeName: Tumor necrosis factor C receptor alternativeName: Tumor necrosis factor receptor 2-related protein alternativeName: Tumor necrosis factor receptor type III shortName: TNF-RIII shortName: TNFR-III |
| geneName | LTBR D12S370 TNFCR TNFR3 TNFRSF3 |
| identifier | P36941 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Apoptosis Disulfide bond Glycoprotein Host-virus interaction Membrane Phosphoprotein Proteomics identification Receptor Reference proteome Repeat Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | LTBR |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8989875] ENSEMBL:ENSG00000111321 LTBR [Homo sapiens] |
| secondaryIdentifier | TNR3_HUMAN B7Z1D2 D3DUR2 F5GXE7 |
| sequenceLength | 435 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P36941-2 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P36941-2 LTBR (8976290)
