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Details on Person UniProt:Q13007-3 IL24
| Class:Id | ReferenceIsoform:8976052 |
|---|---|
| _chainChangeLog | signal peptide:1-51 added on Fri February 17 2017;chain:52-206 added on Fri February 17 2017 |
| _displayName | UniProt:Q13007-3 IL24 |
| _timestamp | 2024-11-03 20:14:51 |
| chain | signal peptide:1-51 chain:52-206 |
| checksum | CB8135083EAB8DDD |
| comment | FUNCTION Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis (PubMed:25168428, PubMed:27687232). Possesses antiviral functions and induces the type I interferon response during influenza infection (PubMed:27687232). Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1 (PubMed:11706020, PubMed:30111632). In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1 (PubMed:25168428). Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal (By similarity). In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2 (By similarity).INTERACTION Up-regulated in melanoma cells induced to terminally differentiate.INDUCTION Upon influenza virus infection.PTM Glycosylated.PTM Ubiquitination at Lys-122 promotes proteasomal degradation.SIMILARITY Belongs to the IL-10 family.ONLINE INFORMATION Interleukin-24 entry |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: Interleukin-24 shortName: IL-24 alternativeName: Melanoma differentiation-associated gene 7 protein shortName: MDA-7 alternativeName: Suppression of tumorigenicity 16 protein |
| geneName | IL24 MDA7 ST16 |
| identifier | Q13007 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Apoptosis Cytokine Direct protein sequencing Disulfide bond Glycoprotein Isopeptide bond Proteomics identification Reference proteome Secreted Signal Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | IL24 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003585] ENSEMBL:ENSG00000162892 IL24 [Homo sapiens] |
| secondaryIdentifier | IL24_HUMAN Q2YHE5 Q53XZ7 Q5YLN8 Q96DB0 Q96KG4 |
| sequenceLength | 206 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q13007-3 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q13007-3 IL24 (8976052)
