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Details on Person UniProt:P51965-3 UBE2E1
| Class:Id | ReferenceIsoform:8975396 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 17 2017;chain:2-193 added on Fri February 17 2017;initiator methionine:1 for 8975396 removed on Fri Nov 03 2023;initiator methionine: for 8975396 added on Fri Nov 03 2023;initiator methionine: for 8975396 removed on Fri Aug 15 2025;initiator methionine:1 for 8975396 added on Fri Aug 15 2025 |
| _displayName | UniProt:P51965-3 UBE2E1 |
| _timestamp | 2025-08-15 21:58:01 |
| chain | initiator methionine:1 chain:2-193 |
| checksum | 2FBC50BE2A6A0008 |
| comment | FUNCTION Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination. Catalyzes monoubiquitination of other proteins in both an E3-dependent and E3-independent manner (PubMed:27237050).CATALYTIC ACTIVITY S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.CATALYTIC ACTIVITY S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.PATHWAY Protein modification; protein ubiquitination.SUBUNIT Interacts with RNF14.INTERACTION ISGylation suppresses ubiquitin E2 enzyme activity.PTM Autoubiquitinated in vitro.SIMILARITY Belongs to the ubiquitin-conjugating enzyme family. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: Ubiquitin-conjugating enzyme E2 E1 ecNumber evidence="7"2.3.2.23 alternativeName: (E3-independent) E2 ubiquitin-conjugating enzyme E1 ecNumber evidence="5"2.3.2.24 alternativeName: E2 ubiquitin-conjugating enzyme E1 alternativeName: UbcH6 alternativeName: Ubiquitin carrier protein E1 alternativeName: Ubiquitin-protein ligase E1 |
| geneName | UBE2E1 UBCH6 |
| identifier | P51965 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing ATP-binding Isopeptide bond Nucleotide-binding Nucleus Proteomics identification Reference proteome Transferase Ubl conjugation Ubl conjugation pathway |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | UBE2E1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990477] ENSEMBL:ENSG00000170142 UBE2E1 [Homo sapiens] |
| secondaryIdentifier | UB2E1_HUMAN B2RBX4 C9J8K2 K4DI90 |
| sequenceLength | 193 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P51965-3 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P51965-3 UBE2E1 (8975396)
