Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:P55854-1 SUMO3
| Class:Id | ReferenceIsoform:8975358 |
|---|---|
| _chainChangeLog | chain:1-92 added on Fri February 17 2017;propeptide:93-103 added on Fri February 17 2017 |
| _displayName | UniProt:P55854-1 SUMO3 |
| _timestamp | 2024-11-03 20:16:54 |
| chain | chain:1-92 propeptide:93-103 |
| checksum | E337E34CB5B3B187 |
| comment | FUNCTION Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4 (PubMed:11451954, PubMed:18538659, PubMed:21965678). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).SUBUNIT Covalently attached to a number of proteins. Interacts with BMAL1 (By similarity). Interacts with USP25 (via ts SIM domain); the interaction sumoylates USP25 and inhibits its ubiquitin hydrolyzing activity. Interacts with SAE2 and UBE2I.INTERACTION Expressed predominantly in liver.PTM Polymeric chains can be formed through Lys-11 cross-linking.PTM Cleavage of precursor form by SENP1, SENP2 or SENP5 is necessary for function.SIMILARITY Belongs to the ubiquitin family. SUMO subfamily.ONLINE INFORMATION SUMO protein entry |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: fullName evidence="14"Small ubiquitin-related modifier 3 shortName evidence="14"SUMO-3 alternativeName: fullName evidence="15"SMT3 homolog 1 alternativeName: fullName evidence="11"SUMO-2 alternativeName: fullName evidence="13"Ubiquitin-like protein SMT3A shortName evidence="13"Smt3A |
| geneName | SUMO3 SMT3A SMT3H1 |
| identifier | P55854 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cytoplasm Isopeptide bond Nucleus Proteomics identification Reference proteome Ubl conjugation Ubl conjugation pathway |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | SUMO3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8961100] ENSEMBL:ENSG00000184900 SUMO3 [Homo sapiens] |
| secondaryIdentifier | SUMO3_HUMAN B2R5X4 B4DUW4 Q53HI9 Q6FGD4 Q9BWR4 |
| sequenceLength | 103 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P55854-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P55854-1 SUMO3 (8975358)
