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Details on Person UniProt:Q13568-3 IRF5
| Class:Id | ReferenceIsoform:8975163 |
|---|---|
| _chainChangeLog | chain:1-498 added on Fri February 17 2017 |
| _displayName | UniProt:Q13568-3 IRF5 |
| _timestamp | 2024-11-03 20:10:22 |
| chain | chain:1-498 |
| checksum | 01B2ED95C28384E8 |
| comment | FUNCTION Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9 (PubMed:11303025, PubMed:15695821, PubMed:22412986, PubMed:25326418, PubMed:32433612). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (By similarity). Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway (By similarity). Key transcription factor regulating the IFN response during SARS-CoV-2 infection (PubMed:33440148).ACTIVITY REGULATION Maintained as a monomer in an autoinhibited state (PubMed:18836453, PubMed:22412986, PubMed:25326418). Phosphorylation and activation follow the following steps: innate adapter protein TASL recruits IRF5, thereby licensing IRF5 for phosphorylation by IKBKB (PubMed:32433612). Phosphorylated IRF5 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce IFNs (PubMed:25326418, PubMed:32433612).ACTIVITY REGULATION (Microbial infection) Activated upon coronavirus SARS-CoV-2 infection.SUBUNIT Homodimer, when phosphorylated (PubMed:18836453, PubMed:25326418). Interacts with TASL (via pLxIS motif); interaction takes place downstream of TLR7, TLR8 or TLR9, leading to its activation (PubMed:32433612). Interacts with MYD88 and TRAF6 (By similarity).INTERACTION Shuttles between the nucleus and the cytoplasm: upon activation by the TLR adapter MYD88 and subsequent phosphorylation, translocates to the nucleus.ALTERNATIVE PRODUCTS Phosphorylation of serine and threonine residues by IKBKB in a C-terminal autoinhibitory region, stimulates dimerization, transport into the nucleus, assembly with the coactivator CBP/EP300 and initiation of transcription.PTM 'Lys-63'-linked polyubiquitination by TRAF6 is required for activation.DISEASE Disease susceptibility is associated with variants affecting the gene represented in this entry.DISEASE Disease susceptibility is associated with variants affecting the gene represented in this entry.DISEASE Disease susceptibility is associated with variants affecting the gene represented in this entry.SIMILARITY Belongs to the IRF family. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: fullName evidence="17"Interferon regulatory factor 5 shortName evidence="17"IRF-5 |
| geneName | IRF5 |
| identifier | Q13568 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Antiviral defense Cytoplasm DNA-binding Immunity Inflammatory response Innate immunity Isopeptide bond Nucleus Phosphoprotein Proteomics identification Reference proteome Systemic lupus erythematosus Transcription Transcription regulation Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | IRF5 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8988445] ENSEMBL:ENSG00000128604 IRF5 [Homo sapiens] |
| secondaryIdentifier | IRF5_HUMAN A4D1J8 A8DUA8 A8DUA9 E7EQ16 E7EW54 Q1A7B4 Q64GA9 Q64GB1 Q64GB2 Q6RCM8 Q9BQF0 |
| sequenceLength | 498 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q13568-3 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q13568-3 IRF5 (8975163)
