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Details on Person UniProt:Q9UBD9-2 CLCF1
| Class:Id | ReferenceIsoform:8975046 |
|---|---|
| _chainChangeLog | signal peptide:1-27 added on Fri February 17 2017;chain:28-225 added on Fri February 17 2017 |
| _displayName | UniProt:Q9UBD9-2 CLCF1 |
| _timestamp | 2024-11-03 19:35:42 |
| chain | signal peptide:1-27 chain:28-225 |
| checksum | E2DD4B6280833B55 |
| comment | FUNCTION In complex with CRLF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (Probable). Also stimulates B-cells. Binds to and activates the ILST/gp130 receptor.SUBUNIT Forms a heteromeric complex with cardiotrophin-like cytokine CRLF1/CLF-1; the CRLF1-CLCF1 complex is a ligand for the ciliary neurotrophic factor receptor/CNTFR (PubMed:26858303). The CRLF1-CLCF1 heterodimer binds SORL1 (via N-terminal ectodomain); within this complex, the interaction is mediated predominantly by the CRLF1 moiety (PubMed:26858303). The tripartite signaling complex formed by CRLF1, CLCF1 and CNTFR also binds SORL1 (PubMed:26858303).INTERACTION Expressed predominantly in lymph nodes, spleen, peripheral blood lymphocytes, bone marrow, and fetal liver.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the IL-6 superfamily. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: Cardiotrophin-like cytokine factor 1 alternativeName: B-cell-stimulating factor 3 shortName: BSF-3 alternativeName: Novel neurotrophin-1 shortName: NNT-1 |
| geneName | CLCF1 BSF3 CLC NNT1 |
| identifier | Q9UBD9 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cytokine Disease variant Glycoprotein Proteomics identification Reference proteome Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CLCF1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001685] ENSEMBL:ENSG00000175505 CLCF1 [Homo sapiens] |
| secondaryIdentifier | CLCF1_HUMAN B4DNT4 Q6NZA4 |
| sequenceLength | 225 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q9UBD9-2 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9UBD9-2 CLCF1 (8975046)
