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Details on Person UniProt:Q4G0U5-1 CFAP221
| Class:Id | ReferenceIsoform:8974827 |
|---|---|
| _chainChangeLog | chain:1-840 added on Fri February 17 2017 |
| _displayName | UniProt:Q4G0U5-1 CFAP221 |
| _timestamp | 2026-02-20 22:36:28 |
| chain | chain:1-840 |
| checksum | 7669C7FA1FFD22E5 |
| comment | FUNCTION May play a role in cilium morphogenesis and ciliary function.SUBUNIT Interacts with calmodulin; calcium-dependent.SUBCELLULAR LOCATION Localizes to the manchette in elongating spermatids in a SPAG17-dependent manner.ALTERNATIVE PRODUCTS Expressed in ciliated respiratory epithelial cells and brain ependymal cells (at protein level).DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the PCDP1 family. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: fullName evidence="13"Cilia- and flagella-associated protein 221 alternativeName: fullName evidence="11"Primary ciliary dyskinesia protein 1 |
| geneName | CFAP221 PCDP1 |
| identifier | Q4G0U5 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Calmodulin-binding Cell projection Ciliopathy Cilium Cilium biogenesis/degradation Cytoplasm Cytoskeleton Primary ciliary dyskinesia Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | CFAP221 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9000755] ENSEMBL:ENSG00000163075 CFAP221 [Homo sapiens] |
| secondaryIdentifier | PCDP1_HUMAN B4DEK0 B4E2T5 |
| sequenceLength | 840 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q4G0U5-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q4G0U5-1 CFAP221 (8974827)
