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Details on Person UniProt:O75251-1 NDUFS7
| Class:Id | ReferenceIsoform:8974789 |
|---|---|
| _chainChangeLog | transit peptide:1-38 added on Fri February 17 2017;chain:39-213 added on Fri February 17 2017 |
| _displayName | UniProt:O75251-1 NDUFS7 |
| _timestamp | 2025-05-21 21:13:36 |
| chain | transit peptide:1-38 chain:39-213 |
| checksum | B3547EA24643C1B0 |
| comment | FUNCTION Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:17275378). Essential for the catalytic activity of complex I (PubMed:17275378).CATALYTIC ACTIVITY a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)COFACTOR Binds 1 [4Fe-4S] cluster.SUBUNIT Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits (PubMed:12611891). This is a component of the iron-sulfur (IP) fragment of the enzyme (By similarity).INTERACTION Hydroxylated at Arg-111 by NDUFAF5 early in the pathway of assembly of complex I, before the formation of the juncture between peripheral and membrane arms.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the complex I 20 kDa subunit family. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial ecNumber evidence="8"7.1.1.2 alternativeName: Complex I-20kD shortName: CI-20kD alternativeName: NADH-ubiquinone oxidoreductase 20 kDa subunit alternativeName: fullName evidence="11"PSST subunit |
| geneName | NDUFS7 |
| identifier | O75251 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure 4Fe-4S Alternative splicing Disease variant Electron transport Hydroxylation Iron Iron-sulfur Leigh syndrome Membrane Metal-binding Mitochondrion Mitochondrion inner membrane NAD Oxidoreductase Primary mitochondrial disease Proteomics identification Reference proteome Respiratory chain Transit peptide Translocase Transport Ubiquinone |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 |
| name | NDUFS7 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993765] ENSEMBL:ENSG00000115286 NDUFS7 [Homo sapiens] |
| secondaryIdentifier | NDUS7_HUMAN B3KRI2 Q2T9H7 Q9BV17 |
| sequenceLength | 213 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | O75251-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O75251-1 NDUFS7 (8974789)
