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Details on Person UniProt:P26640-1 VARS1
| Class:Id | ReferenceIsoform:8974515 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 17 2017;chain:2-1264 added on Fri February 17 2017;initiator methionine:1 for 8974515 removed on Fri Nov 03 2023;initiator methionine: for 8974515 added on Fri Nov 03 2023;initiator methionine: for 8974515 removed on Fri Aug 15 2025;initiator methionine:1 for 8974515 added on Fri Aug 15 2025 |
| _displayName | UniProt:P26640-1 VARS1 |
| _timestamp | 2025-08-15 22:12:19 |
| chain | initiator methionine:1 chain:2-1264 |
| checksum | 95CCDDBB3AB148AD |
| comment | FUNCTION Catalyzes the attachment of valine to tRNA(Val).CATALYTIC ACTIVITY tRNA(Val) + L-valine + ATP = L-valyl-tRNA(Val) + AMP + diphosphateACTIVITY REGULATION Can be regulated by protein kinase C-dependent phosphorylation.SUBUNIT Forms high-molecular-mass aggregates with elongation factor 1.INTERACTION The disease may be caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the class-I aminoacyl-tRNA synthetase family. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: fullName evidence="7"Valine--tRNA ligase ecNumber evidence="4"6.1.1.9 alternativeName: Protein G7a alternativeName: Valyl-tRNA synthetase shortName: ValRS |
| geneName | VARS1 G7A VARS VARS2 |
| identifier | P26640 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Acetylation Alternative splicing Aminoacyl-tRNA synthetase ATP-binding Direct protein sequencing Disease variant Epilepsy Intellectual disability Ligase Nucleotide-binding Phosphoprotein Protein biosynthesis Proteomics identification Reference proteome |
| modified | [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9688885] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9773244] Weiser, Joel [InstanceEdit:9796772] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | VARS1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8960230] ENSEMBL:ENSG00000204394 VARS1 [Homo sapiens] |
| secondaryIdentifier | SYVC_HUMAN B0V1N1 B4DZ61 Q5JQ90 Q96E77 Q9UQM2 |
| sequenceLength | 1264 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P26640-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P26640-1 VARS1 (8974515)
