Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q99471-1 PFDN5
| Class:Id | ReferenceIsoform:8974411 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 17 2017;chain:2-154 added on Fri February 17 2017;initiator methionine:1 for 8974411 removed on Fri Nov 03 2023;initiator methionine: for 8974411 added on Fri Nov 03 2023;initiator methionine: for 8974411 removed on Fri Aug 15 2025;initiator methionine:1 for 8974411 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q99471-1 PFDN5 |
| _timestamp | 2025-08-15 21:17:43 |
| chain | initiator methionine:1 chain:2-154 |
| checksum | 0DA1F3644548CB14 |
| comment | FUNCTION Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC.SUBUNIT Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Binds to MYC; interacts with its N-terminal domain.INTERACTION Additional isoforms seem to exist.TISSUE SPECIFICITY Highly expressed in pancreas and skeletal muscle and moderately in other tissues.MISCELLANEOUS Does not repress transcription activity of MYC.SIMILARITY Belongs to the prefoldin subunit alpha family. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: Prefoldin subunit 5 alternativeName: Myc modulator 1 alternativeName: c-Myc-binding protein Mm-1 |
| geneName | PFDN5 MM1 PFD5 |
| identifier | Q99471 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Chaperone Cytoplasm Nucleus Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | PFDN5 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9000244] ENSEMBL:ENSG00000123349 PFDN5 [Homo sapiens] |
| secondaryIdentifier | PFD5_HUMAN A8K9A8 Q54AA8 Q9C083 Q9C084 |
| sequenceLength | 154 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q99471-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q99471-1 PFDN5 (8974411)
