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Details on Person UniProt:O75144-3 ICOSLG
| Class:Id | ReferenceIsoform:8973829 |
|---|---|
| _chainChangeLog | signal peptide:1-18 added on Fri February 17 2017;chain:19-302 added on Fri February 17 2017 |
| _displayName | UniProt:O75144-3 ICOSLG |
| _timestamp | 2024-11-03 19:56:42 |
| chain | signal peptide:1-18 chain:19-302 |
| checksum | 647934E21B55E34A |
| comment | FUNCTION Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion (PubMed:11007762, PubMed:11023515, PubMed:30498080). Also induces B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity). In endothelial cells, required for proper neutrophil transmigration in response to chemoattractants, such as CXCL8/IL8 or N-formyl-methionyl peptides (fMLP) (PubMed:30498080).SUBUNIT Interacts with CTLA4 (in vitro).INTERACTION Expressed on peripheral blood B-cells and monocytes, as well as on monocyte-derived dendritic cells (at protein level).TISSUE SPECIFICITY Widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil).TISSUE SPECIFICITY Detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells.INDUCTION Constitutive expression is up-regulated by treatment with TNF in peripheral blood B-cells and monocytes, while it is decreased in dendritic cells (PubMed:11007762). In monocytes, up-regulated by CCL3/macrophage inflammatory protein 1-alpha and IFNG (PubMed:10779774).DISEASE The disease may be caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the immunoglobulin superfamily. BTN/MOG family.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION The sequence differs from that shown in position 300 onward for unknown reason. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: ICOS ligand alternativeName: B7 homolog 2 shortName evidence="14"B7-H2 alternativeName: fullName evidence="11"B7-like protein Gl50 alternativeName: B7-related protein 1 shortName evidence="13"B7RP-1 cdAntigenNameCD275/cdAntigenName |
| geneName | ICOSLG B7H2 B7RP1 ICOSL KIAA0653 |
| identifier | O75144 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Adaptive immunity Alternative splicing B-cell activation Cell membrane Disulfide bond Glycoprotein Immunity Immunoglobulin domain Membrane Proteomics identification Reference proteome Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | ICOSLG |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8988437] ENSEMBL:ENSG00000160223 ICOSLG [Homo sapiens] |
| secondaryIdentifier | ICOSL_HUMAN A8MUZ1 Q9HD18 Q9NRQ1 |
| sequenceLength | 302 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | O75144-3 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O75144-3 ICOSLG (8973829)
