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Details on Person UniProt:P08697-1 SERPINF2
| Class:Id | ReferenceIsoform:8973615 |
|---|---|
| _chainChangeLog | signal peptide:1-27 added on Fri February 17 2017;propeptide:28-39 added on Fri February 17 2017;chain:40-491 added on Fri February 17 2017 |
| _displayName | UniProt:P08697-1 SERPINF2 |
| _timestamp | 2024-11-03 20:13:01 |
| chain | signal peptide:1-27 propeptide:28-39 chain:40-491 |
| checksum | 385A1C90E91A63CB |
| comment | FUNCTION Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin.SUBUNIT Forms protease inhibiting heterodimer with TMPRSS7.SUBCELLULAR LOCATION Expressed by the liver and secreted in plasma.PTM Proteolytically cleaved at Pro-39 by both the prolyl endopeptidase FAP form and antiplasmin-cleaving enzyme FAP soluble form to generate mature alpha-2-antiplasmin.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the serpin family. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: Alpha-2-antiplasmin shortName: Alpha-2-AP alternativeName: Alpha-2-plasmin inhibitor shortName: Alpha-2-PI alternativeName: Serpin F2 |
| geneName | SERPINF2 AAP PLI |
| identifier | P08697 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Acute phase Alternative splicing Direct protein sequencing Disease variant Disulfide bond Glycoprotein Isopeptide bond Protease inhibitor Proteomics identification Reference proteome Secreted Serine protease inhibitor Signal Sulfation |
| modified | [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | SERPINF2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8999297] ENSEMBL:ENSG00000167711 SERPINF2 [Homo sapiens] |
| secondaryIdentifier | A2AP_HUMAN B4E1B7 Q8N5U7 Q9UCG2 Q9UCG3 |
| sequenceLength | 491 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P08697-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P08697-1 SERPINF2 (8973615)
