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Details on Person UniProt:Q9H1J5-1 WNT8A
| Class:Id | ReferenceIsoform:8973577 |
|---|---|
| _chainChangeLog | signal peptide:1-24 added on Fri February 17 2017;chain:25-351 added on Fri February 17 2017 |
| _displayName | UniProt:Q9H1J5-1 WNT8A |
| _timestamp | 2025-02-21 19:34:38 |
| chain | signal peptide:1-24 chain:25-351 |
| checksum | B3432171301C17E5 |
| comment | FUNCTION Ligand for members of the frizzled family of seven transmembrane receptors. Plays a role in embryonic patterning.SUBUNIT Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity (PubMed:26902720). The complex with AFM may represent the physiological form in body fluids (PubMed:26902720).SUBCELLULAR LOCATION Palmitoleoylation is required for efficient binding to frizzled receptors (By similarity). Depalmitoleoylation leads to Wnt signaling pathway inhibition (By similarity).PTM Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT8A.MISCELLANEOUS May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.SIMILARITY Belongs to the Wnt family. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: Protein Wnt-8a alternativeName: Protein Wnt-8d |
| geneName | WNT8A WNT8D |
| identifier | Q9H1J5 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Developmental protein Disulfide bond Extracellular matrix Glycoprotein Lipoprotein Reference proteome Secreted Signal Wnt signaling pathway |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | WNT8A |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8995792] ENSEMBL:ENSG00000061492 WNT8A [Homo sapiens] |
| secondaryIdentifier | WNT8A_HUMAN D6RF47 Q96S51 |
| sequenceLength | 351 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q9H1J5-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9H1J5-1 WNT8A (8973577)
