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Details on Person UniProt:Q9Y6Y9-1 LY96
| Class:Id | ReferenceIsoform:8973333 |
|---|---|
| _chainChangeLog | signal peptide:1-18 added on Fri February 17 2017;chain:19-160 added on Fri February 17 2017 |
| _displayName | UniProt:Q9Y6Y9-1 LY96 |
| _timestamp | 2026-02-20 21:41:09 |
| chain | signal peptide:1-18 chain:19-160 |
| checksum | 0F92AFF583637C6B |
| comment | FUNCTION Binds bacterial lipopolysaccharide (LPS) (PubMed:17569869, PubMed:17803912). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria (PubMed:11160242, PubMed:11593030). Enhances TLR4-dependent activation of NF-kappa-B (PubMed:10359581). Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10359581).SUBUNIT Heterogeneous homomer formed from homodimers; disulfide-linked (PubMed:11593030, PubMed:12642668). Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4 (PubMed:11274165). Binds to the extracellular domains of TLR2 and TLR4 (PubMed:10359581, PubMed:11593030, PubMed:17803912). Ligand binding induces interaction with TLR4 and oligomerization of the complex.SUBCELLULAR LOCATION Retained in the extracellular space at the cell surface by interaction with TLR4 (PubMed:10359581).ALTERNATIVE PRODUCTS N-glycosylated; high-mannose. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: Lymphocyte antigen 96 shortName: Ly-96 alternativeName: fullName evidence="13"ESOP-1 alternativeName: fullName evidence="12"Protein MD-2 |
| geneName | LY96 ESOP1 MD2 |
| identifier | Q9Y6Y9 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Disulfide bond Glycoprotein Immunity Inflammatory response Innate immunity Proteomics identification Reference proteome Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | LY96 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8989049] ENSEMBL:ENSG00000154589 LY96 [Homo sapiens] |
| secondaryIdentifier | LY96_HUMAN B3Y6A5 E5RJJ7 |
| sequenceLength | 160 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q9Y6Y9-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9Y6Y9-1 LY96 (8973333)
