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Details on Person UniProt:O43508-1 TNFSF12

Class:IdReferenceIsoform:8973102
_chainChangeLogchain:1-249 added on Fri February 17 2017;chain:94-249 added on Fri February 17 2017
_displayNameUniProt:O43508-1 TNFSF12
_timestamp2024-11-03 20:03:39
chainchain:1-249
chain:94-249
checksumE660843361C28EBA
commentFUNCTION Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion.SUBUNIT Homotrimer (Probable). Interacts with the angiogenic factor AGGF1/VG5Q.INTERACTION Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain.PTM The soluble form derives from the membrane form by proteolytic processing.MISCELLANEOUS Based on a readthrough transcript which may produce a TWE-PRIL (TNFSF12-TNFSF13) fusion protein. Expressed at protein level in primary T-lymphocytes and monocytic cell lines.SIMILARITY Belongs to the tumor necrosis factor family.
created[InstanceEdit:8964659] Weiser, JD
descriptionrecommendedName: Tumor necrosis factor ligand superfamily member 12 alternativeName: APO3 ligand alternativeName: TNF-related weak inducer of apoptosis shortName: TWEAK component recommendedName: Tumor necrosis factor ligand superfamily member 12, membrane form /component component recommendedName: Tumor necrosis factor ligand superfamily member 12, secreted form /component
geneNameTNFSF12
APO3L
DR3LG
UNQ181/PRO207
identifierO43508
isoformParent
isSequenceChangedFALSE
keyword3D-structure
Alternative splicing
Angiogenesis
Apoptosis
Cell membrane
Cleavage on pair of basic residues
Cytokine
Developmental protein
Differentiation
Disulfide bond
Glycoprotein
Membrane
Proteomics identification
Reference proteome
Secreted
Signal-anchor
Transmembrane
Transmembrane helix
modified[InstanceEdit:9836292] Weiser, Joel, 2023-05-25
[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
nameTNFSF12
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:8999222] ENSEMBL:ENSG00000239697 TNFSF12 [Homo sapiens]
secondaryIdentifierTNF12_HUMAN
Q8IZK7
Q8WUZ7
sequenceLength249
species[Species:48887] Homo sapiens
variantIdentifierO43508-1
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