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Details on Person UniProt:Q92734-2 TFG
| Class:Id | ReferenceIsoform:8972610 |
|---|---|
| _chainChangeLog | chain:1-400 added on Fri February 17 2017 |
| _displayName | UniProt:Q92734-2 TFG |
| _timestamp | 2024-11-03 20:21:51 |
| chain | chain:1-400 |
| checksum | D8A559D0F7314D1F |
| comment | FUNCTION Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules (PubMed:23479643, PubMed:27813252). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:21478858).SUBUNIT Self-associates to form an oligomeric complex (PubMed:23479643). Interacts with PDCD6; promoting localization and polymerization of TFG at endoplasmic reticulum exit site (PubMed:27813252). Interacts with SEC16B (PubMed:21478858).INTERACTION Localizes to endoplasmic reticulum exit site (ERES), also known as transitional endoplasmic reticulum (tER) (PubMed:21478858, PubMed:27813252).ALTERNATIVE PRODUCTS Ubiquitous.DISEASE A chromosomal aberration involving TFG is found in papillary thyroid carcinomas (PTCs). Translocation t(1;3)(q21;q11) with NTRK1. The TFG sequence is fused to the 3'-end of NTRK1 generating the TRKT3 (TRK-T3) fusion transcript.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: Protein TFG alternativeName: TRK-fused gene protein |
| geneName | TFG |
| identifier | Q92734 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Chromosomal rearrangement Coiled coil Direct protein sequencing Disease variant Endoplasmic reticulum ER-Golgi transport Hereditary spastic paraplegia Methylation Neurodegeneration Neuropathy Phosphoprotein Proteomics identification Proto-oncogene Reference proteome Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | TFG |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8999204] ENSEMBL:ENSG00000114354 TFG [Homo sapiens] |
| secondaryIdentifier | TFG_HUMAN D3DN49 G5E9V1 K0J5S8 K0J6K2 Q15656 Q969I2 |
| sequenceLength | 400 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q92734-2 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q92734-2 TFG (8972610)
