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Details on Person UniProt:Q13639-8 HTR4
| Class:Id | ReferenceIsoform:8972270 |
|---|---|
| _chainChangeLog | chain:1-388 added on Fri February 17 2017 |
| _displayName | UniProt:Q13639-8 HTR4 |
| _timestamp | 2026-02-20 21:46:25 |
| chain | chain:1-388 |
| checksum | 7FCFEC60E7BDF560 |
| comment | FUNCTION G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:10821780, PubMed:16102731, PubMed:35714614, PubMed:9603189). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:16102731, PubMed:35714614). HTR4 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (PubMed:16102731, PubMed:35714614).SUBUNIT Interacts (via C-terminus 330-346 AA) with GRK5; this interaction is promoted by 5-HT (serotonin).SUBUNIT Interacts with MAGI2, MPP3, NHERF1 and SNX27 isoforms 1 and 2 (By similarity). Forms a complex including NHERF1 and EZR (By similarity).SUBUNIT Interacts with PATJ, NOS1 and SEC23A.INTERACTION Interaction with SNX27 mediates recruitment to early endosomes, while interaction with NHERF1 and EZR might target the protein to specialized subcellular regions, such as microvilli.ALTERNATIVE PRODUCTS Additional isoforms seem to exist.TISSUE SPECIFICITY Expressed in ileum, brain, and atrium, but not in the ventricle.TISSUE SPECIFICITY Mainly expressed in atria and cardiac ventricle.TISSUE SPECIFICITY Expressed in all cardiovascular tissues analyzed.DOMAIN Specificity for G(s) G alpha proteins is determined by the length of transmembrane regions 5 and 6 (TM5 and TM6).SIMILARITY Belongs to the G-protein coupled receptor 1 family. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: fullName evidence="13"5-hydroxytryptamine receptor 4 shortName evidence="11"5-HT-4 shortName evidence="11"5-HT4 alternativeName: fullName evidence="11"Serotonin receptor 4 |
| geneName | HTR4 |
| identifier | Q13639 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell membrane Disulfide bond Endosome G-protein coupled receptor Glycoprotein Membrane Proteomics identification Receptor Reference proteome Transducer Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | HTR4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997564] ENSEMBL:ENSG00000164270 HTR4 [Homo sapiens] |
| secondaryIdentifier | 5HT4R_HUMAN C4WYH4 Q546Q1 Q684M0 Q712M9 Q96KH9 Q96KI0 Q9H199 Q9NY73 Q9UBM6 Q9UBT4 Q9UE22 Q9UE23 Q9UQR6 |
| sequenceLength | 388 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q13639-8 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q13639-8 HTR4 (8972270)
