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Details on Person UniProt:P29372-5 MPG
| Class:Id | ReferenceIsoform:8972268 |
|---|---|
| _chainChangeLog | transit peptide:1-17 added on Fri February 17 2017;chain:18-298 added on Fri February 17 2017 |
| _displayName | UniProt:P29372-5 MPG |
| _timestamp | 2024-11-03 19:59:35 |
| chain | transit peptide:1-17 chain:18-298 |
| checksum | BEA8C4CB250D572B |
| comment | FUNCTION Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.CATALYTIC ACTIVITY Hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine.ACTIVITY REGULATION Binding to SSBP1 in mitochondria inhibits glycosylase activity in the context of a single-stranded DNA (ssDNA), but not a double-stranded DNA (dsDNA) substrates.SUBUNIT Binds MBD1. Binds SSBP1.INTERACTION Experimental confirmation may be lacking for some isoforms.SIMILARITY Belongs to the DNA glycosylase MPG family. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: DNA-3-methyladenine glycosylase ecNumber: 3.2.2.21 alternativeName: 3-alkyladenine DNA glycosylase alternativeName: 3-methyladenine DNA glycosidase alternativeName: ADPG alternativeName: N-methylpurine-DNA glycosylase |
| geneName | MPG AAG ANPG MID1 |
| identifier | P29372 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cytoplasm DNA damage DNA repair Hydrolase Mitochondrion Mitochondrion nucleoid Nucleus Phosphoprotein Proteomics identification Reference proteome Transit peptide |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | MPG |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997561] ENSEMBL:ENSG00000103152 MPG [Homo sapiens] |
| secondaryIdentifier | 3MG_HUMAN G5E9E2 Q13770 Q15275 Q15961 Q5J9I4 Q96BZ6 Q96S33 Q9NNX5 |
| sequenceLength | 298 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P29372-5 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P29372-5 MPG (8972268)
