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Details on Person UniProt:O15105-2 SMAD7
| Class:Id | ReferenceIsoform:8971673 |
|---|---|
| _chainChangeLog | chain:1-426 added on Fri February 17 2017 |
| _displayName | UniProt:O15105-2 SMAD7 |
| _timestamp | 2026-02-20 22:16:12 |
| chain | chain:1-426 |
| checksum | 5B76EC986776C102 |
| comment | FUNCTION Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access (PubMed:21791611). Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.SUBUNIT Interacts with WWP1 (By similarity). Interacts with COPS5. Interacts with NEDD4L. Interacts with STAMBP. Interacts with RNF111, AXIN1 and AXIN2. Interacts with PPP1R15A. Interacts (via MH2 domain) with EP300. Interacts with ACVR1B, SMURF1, SMURF2 and TGFBR1; SMAD7 recruits SMURF1 and SMURF2 to the TGF-beta receptor and regulates its degradation (PubMed:11163210, PubMed:11278251, PubMed:12023024, PubMed:21791611, PubMed:9892009). Interacts with PDPK1 (via PH domain). Interacts with TSC22D1/TSC-22; the interaction requires TGF-beta and the interaction is inhibited by TGFBR1 (PubMed:21791611).INTERACTION Interaction with NEDD4L or RNF111 induces translocation from the nucleus to the cytoplasm (PubMed:16601693). TGF-beta stimulates its translocation from the nucleus to the cytoplasm. PDPK1 inhibits its translocation from the nucleus to the cytoplasm in response to TGF-beta (PubMed:17327236).ALTERNATIVE PRODUCTS Ubiquitous with higher expression in the lung and vascular endothelium.INDUCTION By TGFB1.PTM Phosphorylation on Ser-249 does not affect its stability, nuclear localization or inhibitory function in TGFB signaling; however it affects its ability to regulate transcription (By similarity). Phosphorylated by PDPK1.PTM Ubiquitinated by WWP1 (By similarity). Polyubiquitinated by RNF111, which is enhanced by AXIN1 and promotes proteasomal degradation (PubMed:14657019, PubMed:16601693). In response to TGF-beta, ubiquitinated by SMURF1; which promotes its degradation (PubMed:11278251).PTM Acetylation prevents ubiquitination and degradation mediated by SMURF1.DISEASE Disease susceptibility is associated with variants affecting the gene represented in this entry.SIMILARITY Belongs to the dwarfin/SMAD family. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: fullName evidence="24"SMAD family member 7 shortName evidence="23"SMAD 7 shortName: hSMAD7 alternativeName: Mothers against decapentaplegic homolog 7 shortName: MAD homolog 7 shortName: Mothers against DPP homolog 7 alternativeName: Mothers against decapentaplegic homolog 8 shortName: MAD homolog 8 shortName: Mothers against DPP homolog 8 |
| geneName | SMAD7 MADH7 MADH8 |
| identifier | O15105 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Cytoplasm Isopeptide bond Metal-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation Ubl conjugation Zinc |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | SMAD7 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:2106590] ENSEMBL:ENSG00000101665 SMAD7 [Homo sapiens] |
| secondaryIdentifier | SMAD7_HUMAN B7Z773 K7EQ10 O14740 Q6DK23 |
| sequenceLength | 426 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | O15105-2 |
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No pathways have been reviewed or authored by UniProt:O15105-2 SMAD7 (8971673)
