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Details on Person UniProt:Q15008-4 PSMD6

Class:IdReferenceIsoform:8971640
_chainChangeLoginitiator methionine:1 added on Fri February 17 2017;chain:2-389 added on Fri February 17 2017;initiator methionine:1 for 8971640 removed on Fri Nov 03 2023;initiator methionine: for 8971640 added on Fri Nov 03 2023;initiator methionine: for 8971640 removed on Fri Aug 15 2025;initiator methionine:1 for 8971640 added on Fri Aug 15 2025
_displayNameUniProt:Q15008-4 PSMD6
_timestamp2025-08-15 21:48:09
chaininitiator methionine:1
chain:2-389
checksum8843E6684AE91ACD
commentFUNCTION Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.SUBUNIT Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD6, a base containing 6 ATPases and few additional components.INTERACTION Belongs to the proteasome subunit S10 family.
created[InstanceEdit:8964659] Weiser, JD
descriptionrecommendedName: 26S proteasome non-ATPase regulatory subunit 6 alternativeName: 26S proteasome regulatory subunit RPN7 alternativeName: 26S proteasome regulatory subunit S10 alternativeName: Breast cancer-associated protein SGA-113M alternativeName: Phosphonoformate immuno-associated protein 4 alternativeName: Proteasome regulatory particle subunit p44S10 alternativeName: p42A
geneNamePSMD6
KIAA0107
PFAAP4
identifierQ15008
isoformParent
isSequenceChangedFALSE
keyword3D-structure
Alternative splicing
Proteasome
Proteomics identification
Reference proteome
modified[InstanceEdit:9836292] Weiser, Joel, 2023-05-25
[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
namePSMD6
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:9003170] ENSEMBL:ENSG00000163636 PSMD6 [Homo sapiens]
secondaryIdentifierPSMD6_HUMAN
A8K2E0
E9PHI9
Q6UV22
sequenceLength389
species[Species:48887] Homo sapiens
variantIdentifierQ15008-4
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No pathways have been reviewed or authored by UniProt:Q15008-4 PSMD6 (8971640)
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