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Details on Person UniProt:Q8IUM7-1 NPAS4
| Class:Id | ReferenceIsoform:8971570 |
|---|---|
| _chainChangeLog | chain:1-802 added on Fri February 17 2017 |
| _displayName | UniProt:Q8IUM7-1 NPAS4 |
| _timestamp | 2024-11-03 19:52:53 |
| chain | chain:1-802 |
| checksum | 0F5CB6486D0813F0 |
| comment | FUNCTION Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hippocampus (By similarity). Plays a key role in the structural and functional plasticity of neurons (By similarity). Acts as an early-response transcription factor in both excitatory and inhibitory neurons, where it induces distinct but overlapping sets of late-response genes in these two types of neurons, allowing the synapses that form on inhibitory and excitatory neurons to be modified by neuronal activity in a manner specific to their function within a circuit, thereby facilitating appropriate circuit responses to sensory experience (By similarity). In excitatory neurons, activates transcription of BDNF, which in turn controls the number of GABA-releasing synapses that form on excitatory neurons, thereby promoting an increased number of inhibitory synapses on excitatory neurons (By similarity). In inhibitory neurons, regulates a distinct set of target genes that serve to increase excitatory input onto somatostatin neurons, probably resulting in enhanced feedback inhibition within cortical circuits (By similarity). The excitatory and inhibitory balance in neurons affects a number of processes, such as short-term and long-term memory, acquisition of experience, fear memory, response to stress and social behavior (By similarity). Acts as a regulator of dendritic spine development in olfactory bulb granule cells in a sensory-experience-dependent manner by regulating expression of MDM2 (By similarity). Efficient DNA binding requires dimerization with another bHLH protein, such as ARNT, ARNT2 or BMAL1 (PubMed:14701734). Can activate the CME (CNS midline enhancer) element (PubMed:14701734).SUBUNIT Efficient DNA binding requires dimerization with another bHLH protein (PubMed:14701734, PubMed:24465693). Heterodimer; forms a heterodimer with ARNT, ARNT2 or BMAL1 (PubMed:14701734, PubMed:24465693).SUBCELLULAR LOCATION Brain.PTM Ubiquitinated, leading to degradation by the proteosome. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: fullName evidence="10"Neuronal PAS domain-containing protein 4 shortName evidence="10"Neuronal PAS4 alternativeName: fullName evidence="10"Class E basic helix-loop-helix protein 79 shortName evidence="10"bHLHe79 alternativeName: fullName evidence="8"HLH-PAS transcription factor NXF alternativeName: fullName evidence="10"PAS domain-containing protein 10 |
| geneName | NPAS4 BHLHE79 NXF PASD10 |
| identifier | Q8IUM7 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Activator Alternative splicing Coiled coil Differentiation DNA-binding Neurogenesis Nucleus Proteomics identification Reference proteome Repeat Transcription Transcription regulation Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | NPAS4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8998476] ENSEMBL:ENSG00000174576 NPAS4 [Homo sapiens] |
| secondaryIdentifier | NPAS4_HUMAN B7ZL81 Q8N8S5 Q8N9Q9 |
| sequenceLength | 802 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q8IUM7-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q8IUM7-1 NPAS4 (8971570)
