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Details on Person UniProt:Q06495-1 SLC34A1
| Class:Id | ReferenceIsoform:8971094 |
|---|---|
| _chainChangeLog | chain:1-639 added on Fri February 17 2017 |
| _displayName | UniProt:Q06495-1 SLC34A1 |
| _timestamp | 2026-02-20 22:57:46 |
| chain | chain:1-639 |
| checksum | 65D21D968C35D61B |
| comment | FUNCTION Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane (PubMed:12324554, PubMed:20335586, PubMed:26047794, PubMed:8327470). The cotransport has a Na(+):Pi stoichiometry of 3:1 and is electrogenic (By similarity).CATALYTIC ACTIVITY 3 Na(+)(out) + phosphate(out) = 3 Na(+)(in) + phosphate(in)BIOPHYSICOCHEMICAL PROPERTIES Optimum pH is 8.0.SUBUNIT Interacts via its C-terminal region with NHERF4 (By similarity). Interacts with NHERF1 (PubMed:22506049). Interacts with TMEM174; regulates SLC34A1 internalization by PTH and FGF23 (By similarity).INTERACTION Localized at the brush border membranes of the proximal tubules. Internalized from the cell surface upon PTH stimulation.ALTERNATIVE PRODUCTS Kidney and lung.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the SLC34A transporter family. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: Sodium-dependent phosphate transport protein 2A shortName: Sodium-phosphate transport protein 2A alternativeName: Na(+)-dependent phosphate cotransporter 2A alternativeName: fullName evidence="10"NaPi-3 alternativeName: Sodium/phosphate cotransporter 2A shortName: Na(+)/Pi cotransporter 2A shortName: NaPi-2a alternativeName: fullName evidence="13"Solute carrier family 34 member 1 |
| geneName | SLC34A1 NPT2 SLC17A2 |
| identifier | Q06495 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Cell membrane Disease variant Disulfide bond Glycoprotein Ion transport Membrane Osteoporosis Phosphoprotein Proteomics identification Reference proteome Sodium Sodium transport Symport Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | SLC34A1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001930] ENSEMBL:ENSG00000131183 SLC34A1 [Homo sapiens] |
| secondaryIdentifier | NPT2A_HUMAN B4DPE3 |
| sequenceLength | 639 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q06495-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q06495-1 SLC34A1 (8971094)
