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Details on Person UniProt:Q92556-3 ELMO1
| Class:Id | ReferenceIsoform:8970980 |
|---|---|
| _chainChangeLog | chain:1-727 added on Fri February 17 2017 |
| _displayName | UniProt:Q92556-3 ELMO1 |
| _timestamp | 2024-11-03 19:40:48 |
| chain | chain:1-727 |
| checksum | 053DCA73D2B0A4C6 |
| comment | FUNCTION Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.SUBUNIT Interacts with ADGRB1 (By similarity). Interacts directly with the SH3-domain of DOCK1 via its SH3-binding site. Part of a complex with DOCK1 and RAC1. Part of a complex with DOCK1 and CRK isoform CRK-II. Interacts with PLEKHG6. Interacts with HCK (via SH3 domain). Interacts with ADGRB3 (PubMed:24567399). Interacts with DOCK5 (By similarity).INTERACTION Translocation to plasma membrane seems to be mediated by DOCK1 and CRK.ALTERNATIVE PRODUCTS Widely expressed, with a higher expression in the spleen and placenta.PTM Phosphorylated by HCK. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: Engulfment and cell motility protein 1 alternativeName: Protein ced-12 homolog |
| geneName | ELMO1 KIAA0281 |
| identifier | Q92556 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Apoptosis Cell membrane Cytoplasm Membrane Phagocytosis Phosphoprotein Proteomics identification Reference proteome SH3-binding |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | ELMO1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8992431] ENSEMBL:ENSG00000155849 ELMO1 [Homo sapiens] |
| secondaryIdentifier | ELMO1_HUMAN A4D1X6 Q29R79 Q6ZTJ0 Q96PB0 Q9H0I1 |
| sequenceLength | 727 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q92556-3 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q92556-3 ELMO1 (8970980)
