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Details on Person UniProt:Q15329-1 E2F5
| Class:Id | ReferenceIsoform:8970974 |
|---|---|
| _chainChangeLog | chain:1-346 added on Fri February 17 2017 |
| _displayName | UniProt:Q15329-1 E2F5 |
| _timestamp | 2024-11-03 20:14:11 |
| chain | chain:1-346 |
| checksum | F1408A755E67D879 |
| comment | FUNCTION Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor-initiated signal transduction. It is likely involved in the early responses of resting cells to growth factor stimulation. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis.SUBUNIT Component of the DRTF1/E2F transcription factor complex. Binds cooperatively with DP-1 to E2F sites. Interaction with retinoblastoma protein RB1 or proteins RBL1 and RBL2 inhibits the E2F transactivation domain. Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2.INTERACTION Belongs to the E2F/DP family. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: Transcription factor E2F5 shortName: E2F-5 |
| geneName | E2F5 |
| identifier | Q15329 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Activator Alternative splicing Cilium biogenesis/degradation DNA-binding Nucleus Proteomics identification Reference proteome Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | E2F5 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8994192] ENSEMBL:ENSG00000133740 E2F5 [Homo sapiens] |
| secondaryIdentifier | E2F5_HUMAN E9PBN9 Q16601 Q92756 |
| sequenceLength | 346 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q15329-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q15329-1 E2F5 (8970974)
