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Details on Person UniProt:Q2V419-2 CDKB1-2
| Class:Id | ReferenceIsoform:8970931 |
|---|---|
| _chainChangeLog | chain:1-311 added on Fri February 17 2017 |
| _displayName | UniProt:Q2V419-2 CDKB1-2 |
| _timestamp | 2025-02-21 19:16:28 |
| chain | chain:1-311 |
| checksum | A04E60AEF83E5BB0 |
| comment | FUNCTION Together with CDKB1-1, promotes both the last division in the stomatal cell lineage as well as the number of stomata (PubMed:20675570). In collaboration with MYB124 and MYB88, restrict the G1/S transition and chloroplast and nuclear number during stomatal formation, and normally maintain fate and developmental progression throughout the stomatal cell lineage (PubMed:24123248).CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)CATALYTIC ACTIVITY [DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)SUBUNIT Interacts with CKS1.ALTERNATIVE PRODUCTS Expressed in flowers.DISRUPTION PHENOTYPE No apparent stomatal abnormalities. The double mutant cdkb1;1 cdkb1;2 has a reduced number of abnormal stomata consisting in single guard cells (GC) (PubMed:20675570). The quadruple mutant flp-1 myb88 cdkb1;1 cdkb1;2 has a reduced number of large single guard cells blocked at mitosis, with strongly altered shape and size and characterized by enlarged nucleus due to endomitosis and endocycling, as well as extensive chloroplast replication (PubMed:24123248).SIMILARITY Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.SEQUENCE CAUTION Truncated C-terminus. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: Cyclin-dependent kinase B1-2 shortName: CDKB1;2 ecNumber: 2.7.11.22 ecNumber: 2.7.11.23 |
| geneName | CDKB1-2 At2g38620 T6A23.18 |
| identifier | Q2V419 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing ATP-binding Kinase Nucleotide-binding Phosphoprotein Reference proteome Serine/threonine-protein kinase Transferase |
| modified | [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | CDKB1-2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | CKB12_ARATH Q56XK5 Q9ZVI4 |
| sequenceLength | 311 |
| species | [Species:170905] Arabidopsis thaliana |
| variantIdentifier | Q2V419-2 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q2V419-2 CDKB1-2 (8970931)
