Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:O75489-2 NDUFS3
| Class:Id | ReferenceIsoform:8970638 |
|---|---|
| _chainChangeLog | transit peptide:1-36 added on Fri February 17 2017;chain:37-264 added on Fri February 17 2017 |
| _displayName | UniProt:O75489-2 NDUFS3 |
| _timestamp | 2025-02-21 20:11:59 |
| chain | transit peptide:1-36 chain:37-264 |
| checksum | C058D62779BEF17B |
| comment | FUNCTION Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:14729820, PubMed:30140060). Essential for the catalytic activity and assembly of complex I (PubMed:14729820, PubMed:24028823, PubMed:30140060).CATALYTIC ACTIVITY a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)SUBUNIT Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits (PubMed:12611891). Interacts with NDUFAF3 (PubMed:19463981). Interacts with RAB5IF (PubMed:31536960). Found in subcomplexes containing subunits NDUFS2, MT-ND1 and NDUFA13 (PubMed:17209039, PubMed:18826940).INTERACTION The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the complex I 30 kDa subunit family. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial ecNumber evidence="2 9"7.1.1.2 alternativeName: Complex I-30kD shortName: CI-30kD alternativeName: NADH-ubiquinone oxidoreductase 30 kDa subunit |
| geneName | NDUFS3 |
| identifier | O75489 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Direct protein sequencing Disease variant Electron transport Membrane Mitochondrion Mitochondrion inner membrane NAD Oxidoreductase Primary mitochondrial disease Proteomics identification Reference proteome Respiratory chain Transit peptide Translocase Transport Ubiquinone |
| modified | [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9027688] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9645038] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9688885] Weiser, JD [InstanceEdit:9698430] Weiser, JD [InstanceEdit:9706439] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | NDUFS3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997850] ENSEMBL:ENSG00000213619 NDUFS3 [Homo sapiens] |
| secondaryIdentifier | NDUS3_HUMAN B2R9J1 B4DFM8 Q9UNQ8 |
| sequenceLength | 264 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | O75489-2 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O75489-2 NDUFS3 (8970638)
