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Details on Person UniProt:P07741-1 APRT
| Class:Id | ReferenceIsoform:8970387 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 17 2017;chain:2-180 added on Fri February 17 2017;initiator methionine:1 for 8970387 removed on Fri Nov 03 2023;initiator methionine: for 8970387 added on Fri Nov 03 2023;initiator methionine: for 8970387 removed on Fri Aug 15 2025;initiator methionine:1 for 8970387 added on Fri Aug 15 2025 |
| _displayName | UniProt:P07741-1 APRT |
| _timestamp | 2025-08-15 21:20:53 |
| chain | initiator methionine:1 chain:2-180 |
| checksum | CDC7703337A6E453 |
| comment | FUNCTION Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.CATALYTIC ACTIVITY AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenineBIOPHYSICOCHEMICAL PROPERTIES Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.SUBUNIT Homodimer.INTERACTION The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the purine/pyrimidine phosphoribosyltransferase family.ONLINE INFORMATION Adenine phosphoribosyltransferase entry |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: fullName evidence="14"Adenine phosphoribosyltransferase shortName: APRT ecNumber evidence="4"2.4.2.7 |
| geneName | APRT |
| identifier | P07741 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Cytoplasm Direct protein sequencing Disease variant Glycosyltransferase Phosphoprotein Proteomics identification Purine salvage Reference proteome Transferase |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | APRT |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8994664] ENSEMBL:ENSG00000198931 APRT [Homo sapiens] |
| secondaryIdentifier | APT_HUMAN G5E9J2 Q3KP55 Q68DF9 |
| sequenceLength | 180 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P07741-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P07741-1 APRT (8970387)
