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Details on Person UniProt:P42771-4 CDKN2A
| Class:Id | ReferenceIsoform:8969998 |
|---|---|
| _chainChangeLog | chain:1-156 added on Fri February 17 2017 |
| _displayName | UniProt:P42771-4 CDKN2A |
| _timestamp | 2026-05-15 21:14:29 |
| chain | chain:1-156 |
| checksum | E59C0E6174B48255 |
| comment | FUNCTION Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.SUBUNIT Heterodimer with CDK4 or CDK6. Predominant p16 complexes contained CDK6. Interacts with CDK4 (both 'T-172'-phosphorylated and non-phosphorylated forms); the interaction inhibits cyclin D-CDK4 kinase activity. Interacts with ISCO2.INTERACTION Isoform 1 and isoform tumor suppressor ARF arise due to the use of two alternative first exons joined to a common exon 2 at the same acceptor site but in different reading frames, resulting in two completely different isoforms.TISSUE SPECIFICITY Widely expressed but not detected in brain or skeletal muscle. Isoform 3 is pancreas-specific.PTM Phosphorylation seems to increase interaction with CDK4.DISEASE The association between cutaneous and uveal melanomas in some families suggests that mutations in CDKN2A may account for a proportion of uveal melanomas. However, CDKN2A mutations are rarely found in uveal melanoma patients.DISEASE Disease susceptibility is associated with variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS Barely detectable in non-tumor cells.SIMILARITY Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.CAUTION The proteins described here are encoded by the gene CDKN2A, but are completely unrelated in terms of sequence and function to tumor suppressor ARF (AC Q8N726) which is encoded by the same gene.SEQUENCE CAUTION Truncated N-terminus.ONLINE INFORMATION P16INK4a entry |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: fullName evidence="27"Cyclin-dependent kinase inhibitor 2A alternativeName: Cyclin-dependent kinase 4 inhibitor A shortName: CDK4I alternativeName: Multiple tumor suppressor 1 shortName: MTS-1 alternativeName: p16-INK4a shortName: p16-INK4 shortName: p16INK4A |
| geneName | CDKN2A CDKN2 MTS1 |
| identifier | P42771 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing ANK repeat Cell cycle Cytoplasm Disease variant Li-Fraumeni syndrome Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Tumor suppressor |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 [InstanceEdit:9970787] Weiser, Joel, 2025-10-31 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 [InstanceEdit:9989145] Weiser, Joel, 2026-05-15 |
| name | CDKN2A |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:3200016] ENSEMBL:ENSG00000147889 CDKN2A [Homo sapiens] |
| secondaryIdentifier | CDN2A_HUMAN A5X2G7 D3DRK1 G3XAG3 O95440 Q15191 Q5VVJ5 Q96B52 Q9NP05 |
| sequenceLength | 156 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P42771-4 |
| (isoformParent) | [ReferenceIsoform:411347] UniProt:Q8N726-1 CDKN2A [Homo sapiens] [ReferenceIsoform:8965065] UniProt:Q8N726-2 CDKN2A [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P42771-4 CDKN2A (8969998)
