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Details on Person UniProt:Q9Y3Q7-3 ADAM18
| Class:Id | ReferenceIsoform:8969934 |
|---|---|
| _chainChangeLog | signal peptide:1-16 added on Fri February 17 2017;propeptide:17-184 added on Fri February 17 2017;chain:185-739 added on Fri February 17 2017 |
| _displayName | UniProt:Q9Y3Q7-3 ADAM18 |
| _timestamp | 2024-08-09 18:58:46 |
| chain | signal peptide:1-16 propeptide:17-184 chain:185-739 |
| checksum | 2D8BE9A975072CDD |
| comment | FUNCTION Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein (By similarity).SUBCELLULAR LOCATION Expressed specifically in testis.DOMAIN A tripeptide motif (ECD) within disintegrin-like domain could be involved in the binding to egg integrin receptor and thus could mediate sperm/egg binding.PTM The prodomain and the metalloprotease-like domain are cleaved during the epididymal maturation of the spermatozoa. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: Disintegrin and metalloproteinase domain-containing protein 18 shortName: ADAM 18 alternativeName: Transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein III shortName: tMDC III |
| geneName | ADAM18 TMDC3 UNQ858/PRO1867 |
| identifier | Q9Y3Q7 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Developmental protein Differentiation Disulfide bond EGF-like domain Glycoprotein Membrane Proteomics identification Reference proteome Signal Spermatogenesis Transmembrane Transmembrane helix |
| modified | [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 |
| name | ADAM18 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001585] ENSEMBL:ENSG00000168619 ADAM18 [Homo sapiens] |
| secondaryIdentifier | ADA18_HUMAN B2R9Y0 Q0VAI4 Q6IRW9 Q6UXJ9 |
| sequenceLength | 739 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q9Y3Q7-3 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9Y3Q7-3 ADAM18 (8969934)
