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Details on Person UniProt:O43242-1 PSMD3
| Class:Id | ReferenceIsoform:8969820 |
|---|---|
| _chainChangeLog | chain:1-534 added on Fri February 17 2017 |
| _displayName | UniProt:O43242-1 PSMD3 |
| _timestamp | 2024-11-03 19:53:26 |
| chain | chain:1-534 |
| checksum | 3B3FB5593542C078 |
| comment | FUNCTION Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.SUBUNIT Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD3, a base containing 6 ATPases and few additional components (PubMed:27342858, PubMed:27428775). Interacts with UBQLN1 (via ubiquitin-like domain) (PubMed:15147878). Interacts with ERCC6 (PubMed:26030138).INTERACTION Belongs to the proteasome subunit S3 family. |
| created | [InstanceEdit:8964659] Weiser, JD |
| description | recommendedName: 26S proteasome non-ATPase regulatory subunit 3 alternativeName: 26S proteasome regulatory subunit RPN3 alternativeName: 26S proteasome regulatory subunit S3 alternativeName: Proteasome subunit p58 |
| geneName | PSMD3 |
| identifier | O43242 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Isopeptide bond Phosphoprotein Proteasome Proteomics identification Reference proteome Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | PSMD3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002568] ENSEMBL:ENSG00000108344 PSMD3 [Homo sapiens] |
| secondaryIdentifier | PSMD3_HUMAN B3KMW9 B4DT72 Q96EI2 Q9BQA4 |
| sequenceLength | 534 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | O43242-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O43242-1 PSMD3 (8969820)
